A five-microRNA signature identified from genome-wide serum microRNA expression profiling serves as a fingerprint for gastric cancer diagnosis Rui Liu,

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A five-microRNA signature identified from genome-wide serum microRNA expression profiling serves as a fingerprint for gastric cancer diagnosis Rui Liu, Chunni Zhang, Zhibin Hu, Gou Li, Cheng Wang, Cuihua Yang, Dingzhi Huang, Xi Chen, Haiyang Zhang, Rui Zhuang, Ting Deng, Hua Liu, Jingjing Yin, Sufen Wang, Ke Zen, Yi Ba, Chen-Yu Zhang European Journal of Cancer Volume 47, Issue 5, Pages 784-791 (March 2011) DOI: 10.1016/j.ejca.2010.10.025 Copyright © 2010 Elsevier Ltd Terms and Conditions

Fig. 1 A flow chart of the experimental design. European Journal of Cancer 2011 47, 784-791DOI: (10.1016/j.ejca.2010.10.025) Copyright © 2010 Elsevier Ltd Terms and Conditions

Fig. 2 (A–E) Detection of gastric cancer (GC) using the five-serum microRNA (miRNA) profile as a biomarker. Serum levels of the five miRNAs were measured in 164 GC cases and 127 healthy control subjects (in both the training set and the validation set) using a hydrolysis probe-based qRT-PCR assay. CT values were converted to an absolute value based on the standard curve. (F) Risk score values in GC patients between stages I, II and III, IV. ∗∗P<0.01. European Journal of Cancer 2011 47, 784-791DOI: (10.1016/j.ejca.2010.10.025) Copyright © 2010 Elsevier Ltd Terms and Conditions

Fig. 3 (A and B) Receiver operating characteristic (ROC) curves for the five-serum miRNA profile to distinguish GC serum samples from control serum samples in the training set (A) and the validation set (B). (C and D) ROC curves for carcinoembryonic antigen (CEA) (C) and carbohydrate antigen 19-9 (CA19-9) (D) to distinguish GC serum samples from control serum samples. European Journal of Cancer 2011 47, 784-791DOI: (10.1016/j.ejca.2010.10.025) Copyright © 2010 Elsevier Ltd Terms and Conditions