John W. Pickering, PhD, Matthew T. James, MD, PhD, FRCPC, Suetonia C

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Acute Kidney Injury and Prognosis After Cardiopulmonary Bypass: A Meta-analysis of Cohort Studies John W. Pickering, PhD, Matthew T. James, MD, PhD, FRCPC, Suetonia C. Palmer, MBChB, PhD American Journal of Kidney Diseases Volume 65, Issue 2, Pages 283-293 (February 2015) DOI: 10.1053/j.ajkd.2014.09.008 Copyright © 2015 National Kidney Foundation, Inc. Terms and Conditions

Figure 1 Flow diagram; the process to identify eligible studies. Note: Some studies report more than one acute kidney injury (AKI) definition or one outcome. Abbreviations: AKIN, Acute Kidney Injury Network definition; AMI, acute myocardial infarction; CPB, cardiopulmonary bypass; CHF, congestive heart failure; Hosp, hospitalization; RRT, renal replacement therapy; SI, study investigator definition; RIFLE, risk, injury, failure, loss, end-stage renal disease definition. American Journal of Kidney Diseases 2015 65, 283-293DOI: (10.1053/j.ajkd.2014.09.008) Copyright © 2015 National Kidney Foundation, Inc. Terms and Conditions

Figure 2 Early mortality risk following cardiopulmonary bypass–associated acute kidney injury (primary outcome). Abbreviations: AKIN, Acute Kidney Injury Network definition; CI, confidence interval; RIFLE, risk, injury, failure, loss, end-stage renal disease definition. American Journal of Kidney Diseases 2015 65, 283-293DOI: (10.1053/j.ajkd.2014.09.008) Copyright © 2015 National Kidney Foundation, Inc. Terms and Conditions

Figure 3 Early mortality risk following renal replacement therapy. Abbreviation: CI, confidence interval. American Journal of Kidney Diseases 2015 65, 283-293DOI: (10.1053/j.ajkd.2014.09.008) Copyright © 2015 National Kidney Foundation, Inc. Terms and Conditions

Figure 4 Risk of stroke following cardiopulmonary bypass–associated acute kidney injury. ∗Nonadjusted outcomes. Abbreviation: CI, confidence interval. American Journal of Kidney Diseases 2015 65, 283-293DOI: (10.1053/j.ajkd.2014.09.008) Copyright © 2015 National Kidney Foundation, Inc. Terms and Conditions