The patient should look up to prevent the medication from first “hitting“ the cornea, which stimulates tearing and dilutes the medication. One drop of solution or a “match head“ amount of ointment should be placed in the inferior cul-de-sac, without touching the bottle to the lashes or eyelids (to prevent contamination). Source: Chapter 22. Ophthalmic Therapeutics, Vaughan & Asbury's General Ophthalmology, 18e Citation: Riordan-Eva P, Cunningham ET, Jr. Vaughan & Asbury's General Ophthalmology, 18e; 2011 Available at: https://accessmedicine.mhmedical.com/DownloadImage.aspx?image=/data/Books/rior18/rior18_c022f002.png&sec=40235169&BookID=387&ChapterSecID=40229339&imagename= Accessed: October 08, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved