Atorvastatin for high-risk statin-naïve patients undergoing noncardiac surgery: The Lowering the Risk of Operative Complications Using Atorvastatin Loading.

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Presentation transcript:

Atorvastatin for high-risk statin-naïve patients undergoing noncardiac surgery: The Lowering the Risk of Operative Complications Using Atorvastatin Loading Dose (LOAD) randomized trial Otavio Berwanger, MD, PhD, Pedro G.M. de Barros e Silva, MD, MHS, PhD, Roberto Ramos Barbosa, MD, Dalton Bertolim Precoma, MD, PhD, Estêvão Lanna Figueiredo, MD, MSC, Ludhmila Abrahão Hajjar, MD, PhD, Cleber Dario Pinto Kruel, MD, PhD, Carolina Alboim, MD, PhD, Adail Paixão Almeida, MD, Marianna Deway Andrade Dracoulakis, MD, PhD, Hugo Vargas Filho, MD, Maria José Carvalho Carmona, MD, PhD, Lília Nigro Maia, MD, PhD, João Bosco de Oliveira Filho, MD, PhD, Jose Francisco Kerr Saraiva, MD, PhD, Rafael M. Soares, RD, MSc, Lucas Damiani, STAT, MSC, Denise Paisani, MT, PhD, Alessandra A. Kodama, IT, Beatriz Gonzales, R.PH, Dimas T. Ikeoka, MD, PhD, Philip J. Devereaux, MD, PhD, Renato D. Lopes, MD, MHS, PhD American Heart Journal Volume 184, Pages 88-96 (February 2017) DOI: 10.1016/j.ahj.2016.11.001 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Trial flow diagram. American Heart Journal 2017 184, 88-96DOI: (10.1016/j.ahj.2016.11.001) Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 2 Kaplan-Meyer estimates for the primary outcome. American Heart Journal 2017 184, 88-96DOI: (10.1016/j.ahj.2016.11.001) Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 3 Landmark analysis of the primary outcome. American Heart Journal 2017 184, 88-96DOI: (10.1016/j.ahj.2016.11.001) Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 4 Subgroup analysis of the primary outcome. American Heart Journal 2017 184, 88-96DOI: (10.1016/j.ahj.2016.11.001) Copyright © 2016 Elsevier Inc. Terms and Conditions