From: Will Cell Reprogramming Resolve the Embryonic Stem Cell Controversy? A Narrative Review Ann Intern Med. 2011;155(2):114-121. doi:10.7326/0003-4819-155-2-201107190-00007 Figure Legend: Derivation and medical use of iPS cells.Somatic cells can be reprogrammed into iPS cells and then differentiated into the desired functional cell type. If necessary, genetic defects may be corrected with gene therapy. Cells derived in this manner may have various uses, including autologous and allogeneic cell transplantation, in vitro disease modeling, drug screening, and regeneration research. Figures were produced using Servier Medical Art, available at www.servier.com. iPS cells = induced pluripotent stem cells. Date of download: 10/6/2017 Copyright © American College of Physicians. All rights reserved.