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From: Neuroprotective Effects of Voluntary Exercise in an Inherited Retinal Degeneration Mouse Model Invest. Ophthalmol. Vis. Sci.. 2015;56(11):6839-6846. doi:10.1167/iovs.15-16792 Figure Legend: ANA-12 treatment negated neuroprotective effects of exercise in rd10 mice. Retinal cross-sections of active + vehicle (A) rd10 mice showed visibly greater preservation of ONL morphology than those of inactive + vehicle (B), active + ANA-12 (C), and inactive + ANA-12 (D) rd10 mice. (E) The OKT spatial frequency thresholds measured at P41 showed active + vehicle mice had significantly greater spatial frequency thresholds than all other groups (one-way ANOVA, F[3, 28] = 11.51, P < 0.001). Importantly, ANA+12 treatment completely blocked the protective effects of exercise in the active + ANA-12 mice, such that they were statistically indistinguishable from the inactive treatment groups. (F) Summed photoreceptor nuclei across all locations revealed that active + vehicle rd10 mice had statistically more photoreceptors than all other experimental groups (one-way ANOVA, F(3, 15) = 5.94, P = 0.01], which were statistically indistinguishable from each other. (G) Active vehicle rd10 mice possessed significantly greater summed cone nuclei than inactive vehicle and inactive ANA-12 mice (one-way ANOVA, F[3, 13] = 10.73, P < 0.01). Significant differences were not found between active vehicle and active ANA-12 groups. **P < 0.01; ***P < 0.001. Date of download: 10/4/2017 The Association for Research in Vision and Ophthalmology Copyright © 2017. All rights reserved.