Panimmunoglobulin and IgE-selective extracorporeal immunoadsorption in patients with severe atopic dermatitis Kristian Reich, MD, PhD, Julia Deinzer,

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Panimmunoglobulin and IgE-selective extracorporeal immunoadsorption in patients with severe atopic dermatitis Kristian Reich, MD, PhD, Julia Deinzer, MD, Anne-Kathrin Fiege, MD, Valerie von Gruben, MD, Anna-Lena Sack, MD, Alice Thraen, MD, Peter Weisenseel, MD, Kristine Breuer, MD, PhD, Stefan Jäckle, MD, PhD, Markus Meier, MD, PhD Journal of Allergy and Clinical Immunology Volume 137, Issue 6, Pages 1882-1884.e6 (June 2016) DOI: 10.1016/j.jaci.2016.01.016 Copyright © 2016 The Authors Terms and Conditions

Fig 1 Schematic illustration of the immunoadsorption (IA) procedure. Shown are the 3 immunoadsorption cycles (IA 1 to IA 3; the given days represent the duration of each cycle) and visits 1 to 4, which were used for collection of clinical data (median days and range relative to immunoadsorption cycles). Journal of Allergy and Clinical Immunology 2016 137, 1882-1884.e6DOI: (10.1016/j.jaci.2016.01.016) Copyright © 2016 The Authors Terms and Conditions

Fig 2 Clinical effects of immunoadsorption. EASI and DLQI over time (medians and 95% CIs; upper panels) and percentages of EASI responders (EASI50) and DLQI responders (DLQI ≤ 5) over time (medians and 95% CIs; lower panels) are shown. For time points of visits 1 to 4, see Fig 1. Journal of Allergy and Clinical Immunology 2016 137, 1882-1884.e6DOI: (10.1016/j.jaci.2016.01.016) Copyright © 2016 The Authors Terms and Conditions

Fig E1 Effect of immunoadsorption (IA) on peripheral immunoglobulin levels. Box plots and means of peripheral IgE (upper panels) and IgG (lower panels) levels before and after each immunoadsorption cycle in patients receiving IgE-selective immunoadsorption (left panels) and pan-Ig immunoadsorption (right panels) are shown. Journal of Allergy and Clinical Immunology 2016 137, 1882-1884.e6DOI: (10.1016/j.jaci.2016.01.016) Copyright © 2016 The Authors Terms and Conditions

Fig E2 Comparison of clinical and HR-QoL scores used during immunoadsorption. Box plots and means of relative reductions of clinical scores (EASI and objective SCORAD scores) and HR-QoL parameters (DLQI and POEM scores) at visit 3 compared with baseline (visit 1) are shown. Journal of Allergy and Clinical Immunology 2016 137, 1882-1884.e6DOI: (10.1016/j.jaci.2016.01.016) Copyright © 2016 The Authors Terms and Conditions

Fig E3 Parameters influencing response to immunoadsorption. The illustration shows the estimated probability of the EASI50 response after immunoadsorption treatment related to the presence of 0, 1, 2, or 3 of the following baseline parameters determined by means of logistic regression analysis: (1) EASI of 17 or greater; (2) consumption of at least 1 systemic medication; and (3) peripheral IgE level of less than 6700 kU/L. The highest EASI50 response probability of 75% was calculated for patients with all 3 parameters at baseline. Journal of Allergy and Clinical Immunology 2016 137, 1882-1884.e6DOI: (10.1016/j.jaci.2016.01.016) Copyright © 2016 The Authors Terms and Conditions