Intramyocardial bone marrow mononuclear cell transplantation in ischemic heart failure: Long-term follow-up Miia Lehtinen, MD, Tommi Pätilä, MD, PhD,

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Intramyocardial bone marrow mononuclear cell transplantation in ischemic heart failure: Long-term follow-up Miia Lehtinen, MD, Tommi Pätilä, MD, PhD, Esko Kankuri, MD, PhD, Kirsi Lauerma, MD, PhD, Juha Sinisalo, MD, PhD, Mika Laine, MD, PhD, Markku Kupari, MD, PhD, Antti Vento, MD, PhD, Ari Harjula, MD, PhD The Journal of Heart and Lung Transplantation Volume 34, Issue 7, Pages 899-905 (July 2015) DOI: 10.1016/j.healun.2015.01.989 Copyright © 2015 International Society for Heart and Lung Transplantation Terms and Conditions

Figure 1 Study flow-diagram. BMMC, bone marrow mononuclear cell; CABG, coronary artery bypass grafting; ICD, implantable cardioverter-defibrillator; MRI, magnetic resonance imaging; PM, pacemaker. The Journal of Heart and Lung Transplantation 2015 34, 899-905DOI: (10.1016/j.healun.2015.01.989) Copyright © 2015 International Society for Heart and Lung Transplantation Terms and Conditions

Figure 2 Means and standard deviations (whiskers) of scores for different dimensions of the Medical Outcomes Study Short-Form 36 (SF-36) health-related quality of life questionnaire for placebo-treated control patients, patients treated with bone marrow mononuclear cells (BMMCs), and a reference cohort. The Journal of Heart and Lung Transplantation 2015 34, 899-905DOI: (10.1016/j.healun.2015.01.989) Copyright © 2015 International Society for Heart and Lung Transplantation Terms and Conditions

Figure 3 (A) Left ventricular ejection fraction and (B) left ventricular end-diastolic volume (EDV) and end-systolic volume (ESV) are shown pre-operatively (Pre) and after long-term follow-up in 2013 (Post) in both groups. The horizontal line in the middle of each box indicates the median, the box boarders indicate the 75th and 25th quartiles, and the whiskers indicate the range. BMMC, bone marrow mononuclear cells. The Journal of Heart and Lung Transplantation 2015 34, 899-905DOI: (10.1016/j.healun.2015.01.989) Copyright © 2015 International Society for Heart and Lung Transplantation Terms and Conditions

Figure 4 Scar size preoperatively (Pre) and after long-term follow up in 2013 (Post) in injected (placebo or bone marrow mononuclear cells [BMMC]), non-injected, and all segments in total in both study groups. The horizontal line in the middle of each box indicates the median, the box boarders indicate the 75th and 25th quartiles, and the whiskers indicate the range. The Journal of Heart and Lung Transplantation 2015 34, 899-905DOI: (10.1016/j.healun.2015.01.989) Copyright © 2015 International Society for Heart and Lung Transplantation Terms and Conditions

Figure 5 The trend of change in mean (A) left ventricular end-diastolic volume (LVEDV), (B) left ventricular end-systolic volume (LVESV), (C) left ventricular ejection fraction (LVEF), and (D) scar size in the injected segments pre-operatively (Pre) and at post-operative assessments after 1-year of follow-up (1 y) and after long-term follow-up in 2013. *p < 0.05 (statistically significant difference between the groups). BMMC, bone marrow mononuclear cells. The Journal of Heart and Lung Transplantation 2015 34, 899-905DOI: (10.1016/j.healun.2015.01.989) Copyright © 2015 International Society for Heart and Lung Transplantation Terms and Conditions