Early Inhibitory Effects of Zoledronic Acid in Tooth Extraction Sockets in Dogs Are Negated by Recombinant Human Bone Morphogenetic Protein David A.

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Presentation transcript:

Early Inhibitory Effects of Zoledronic Acid in Tooth Extraction Sockets in Dogs Are Negated by Recombinant Human Bone Morphogenetic Protein David A. Gerard, MS, PhD, Eric R. Carlson, DMD, MD, Jack E. Gotcher, DMD, PhD, David O. Pickett, DMD, MS Journal of Oral and Maxillofacial Surgery Volume 72, Issue 1, Pages 61-66 (January 2014) DOI: 10.1016/j.joms.2013.06.192 Copyright © 2014 American Association of Oral and Maxillofacial Surgeons Terms and Conditions

Figure 1 Schematic of tooth extraction socket showing different areas for analysis. 1, “Reactive” woven bone owing to the regional acceleratory phenomenon; 2, tooth extraction socket; 3, cortical bone; 4, trabecular bone and marrow; 5, mandibular neurovascular bundle; A, apical 4-mm area analyzed for bone volume; B, area analyzed for bone remodeling and apposition rates. Journal of Oral and Maxillofacial Surgery 2014 72, 61-66DOI: (10.1016/j.joms.2013.06.192) Copyright © 2014 American Association of Oral and Maxillofacial Surgeons Terms and Conditions

Figure 2 Subperiosteal bone formation adjacent to the tooth extraction socket owing to the regional acceleratory phenomenon in group II (tetracycline double label; epifluorescence; original magnification, ×100). Journal of Oral and Maxillofacial Surgery 2014 72, 61-66DOI: (10.1016/j.joms.2013.06.192) Copyright © 2014 American Association of Oral and Maxillofacial Surgeons Terms and Conditions

Figure 3 Bone remodeling in region B near the tooth extraction socket in group III (tetracycline double label; epifluorescence; original magnification, ×100). Journal of Oral and Maxillofacial Surgery 2014 72, 61-66DOI: (10.1016/j.joms.2013.06.192) Copyright © 2014 American Association of Oral and Maxillofacial Surgeons Terms and Conditions

Figure 4 A, Rib section and B, femur section from group III (tetracycline double label; epifluorescence; original magnification, ×100). Journal of Oral and Maxillofacial Surgery 2014 72, 61-66DOI: (10.1016/j.joms.2013.06.192) Copyright © 2014 American Association of Oral and Maxillofacial Surgeons Terms and Conditions