Principio isohídrico AMORTIGUACIÓN (Buffers)

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Presentation transcript:

Principio isohídrico

AMORTIGUACIÓN (Buffers)

ECUACIÓN DE HENDERSON - HASSELBACH Principio isohídrico Riñones Pulmones

COMPENSACIÓN (Pulmones)

CORRECCIÓN (Riñones)

(Glutamina)

LEC TUBULO Buffer FOSFATO pK 6.8, pH 6.0 – 7.4 HPO4-- K+ Na+ H+ CO3H- H2O NaH2PO4 K+ LEC TUBULO

TUBULO LEC Buffer AMONIO Cl- Na+ H+ CO3H- NH3 CO3H2 Glutamina NH4 CO2 H2O NH4Cl LEC TUBULO Cl- Glutamina (desaminación) NH3 NH4 Buffer AMONIO

ASOCIACIONES (con otros electrolitos)

ASOCIACIÓN H+ - Ca2+ ESQUEMA SIMPLIFICADO Proteína  [H+]  ↓ pH   [Ca2+] por desplazamiento

ASOCIACIÓN H+ - Ca2+ ESQUEMA SIMPLIFICADO Proteína ↓ [H+]   pH  ↓ [Ca2+] por desplazamiento

EXCITACIÓN NEURONAL 7.0 7.4 7.8 Acidosis Alcalosis COMA CONVULSIONES

4 5 Iónico Difusible Activo Albúmina Ligado Inactivo ASTENIA Acidosis Alcalosis ASTENIA TETANIA

Asociación H+ - K+

Asociación H+ - Cl-

Respuesta Compensatoria Alcalosis Respiratoria Acidosis Respiratoria pH pCO2 HCO3- Respuesta Compensatoria Acidosis Metabólica ⇩ ┴ o ⇩ Alcalosis Respiratoria Acidosis Respiratoria ⇧ ┴ o ⇧ Alcalosis Metabólica