IL-7 induces rapid clathrin-mediated internalization and JAK3-dependent degradation of IL-7Rα in T cells by Catarina M. Henriques, José Rino, Robert J.

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Presentation transcript:

IL-7 induces rapid clathrin-mediated internalization and JAK3-dependent degradation of IL-7Rα in T cells by Catarina M. Henriques, José Rino, Robert J. Nibbs, Gerry J. Graham, and João T. Barata Blood Volume 115(16): April 22, 2010 ©2010 by American Society of Hematology

IL-7 induces rapid IL-7Rα surface down-regulation resulting from receptor internalization. Catarina M. Henriques et al. Blood 2010;115: ©2010 by American Society of Hematology

IL-7Rα internalization via clathrin-coated pits and trafficking into early endosomes is required for efficient IL-7–mediated signaling. Catarina M. Henriques et al. Blood 2010;115: ©2010 by American Society of Hematology

A pool of internalized IL-7Rα recycles to the cell surface. Catarina M. Henriques et al. Blood 2010;115: ©2010 by American Society of Hematology

IL-7 stimulation accelerates IL-7Rα degradation, in a lysosome and proteasome-dependent manner. Catarina M. Henriques et al. Blood 2010;115: ©2010 by American Society of Hematology

IL-7–induced IL-7Rα degradation, but not internalization, is JAK3 dependent. Catarina M. Henriques et al. Blood 2010;115: ©2010 by American Society of Hematology

Proposed model for IL-7Rα trafficking. Catarina M. Henriques et al. Blood 2010;115: ©2010 by American Society of Hematology

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