Date of download: 9/19/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Glycated Hemoglobin Measurement and Prediction of Cardiovascular Disease JAMA. 2014;311(12): doi: /jama Hazard Ratios for Incident Cardiovascular Disease (CVD) Outcomes by Baseline Levels of Glycemia MeasuresAnalyses were adjusted for age, smoking status, systolic blood pressure, total cholesterol level, and high-density lipoprotein cholesterol level and stratified by sex and trial group where appropriate. Participants were classified into groups of (1) HbA1c% (mmol/mol): <4.5 (<25.7), 4.5 to <5 (25.7-<31.1), 5 to <5.5 (31.1-<36.3) [reference category], 5.5 to <6 (36.6-<42.1), 6 to <6.5 (42.1-<48.0), and ≥6.5 (≥48.0); (2) fasting glucose (mg/dL): <76, 76 to <90, 90 to <105 [reference category], 105 to <119, 119 to <133, ≥133; (3) random glucose (mg/dL) <68, 68 to <90, 90 to <112 [reference category], 112 to <133, 133 to <155, ≥155; (4) Postload glucose (mg/dL): <68, 68 to <108, 108 to <148 [reference category], 148 to <187, 187 to <227, ≥227. These categories approximately correspond to 1-SD increments for each factor. Incident CVD outcomes refer to first-onset CVD cases, defined as fatal or nonfatal coronary heart disease or any stroke. SI conversion factors: To convert glucose values to mmol/L, multiply by Sizes of boxes are proportional to the inverse of the variance. Figure Legend:

Date of download: 9/19/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Glycated Hemoglobin Measurement and Prediction of Cardiovascular Disease JAMA. 2014;311(12): doi: /jama Hazard Ratios for Incident Cardiovascular Disease for Glycemia Measures by Selected Study-Level CharacteristicsParticipants with levels of glycemia measures below the mean were excluded. Baseline SD was used to calculate per-SD hazard ratio (HR). Analyses were conducted using studies with information across all levels of each subgroup variable. DCCT indicates Diabetes Control and Complications Trial; HPLC, high-performance liquid chromatography; ITA, immunoturbidimetric assay. A full list of the characteristics examined for heterogeneity is provided in eFigures 5 through 8 in Supplement. Figure Legend:

Date of download: 9/19/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Glycated Hemoglobin Measurement and Prediction of Cardiovascular Disease JAMA. 2014;311(12): doi: /jama Changes in Cardiovascular Disease Risk Discrimination After the Addition of Information on Glycemia Measures to Conventional Risk FactorsIncident cardiovascular disease outcomes refer to first-onset cardiovascular disease cases, defined as fatal or nonfatal coronary heart disease event or any stroke. Studies with missing self-reported diabetes information were excluded. a Conventional risk factors include age, sex (stratified), smoking status, systolic blood pressure, and levels of total cholesterol and high-density lipoprotein cholesterol. b P <.05 c P <.001. Figure Legend: