Success rates

% Clinical Pregnancy Rates The IVF Pathway Success Rates 1.1.14 - 31.12.14 % Clinical Pregnancy Rates This slide demonstrates the clinical pregnancy rates per cycle started and per embryo transfer performed over the past year in this unit You can see that success rates are very much age related The CPR is higher per embryo transferred because not everyone who started a cycle ended up with a transfer. These include women who have come for pre-cancer treatment emergency embryo storage whose embryos were frozen as well as a small number who did not have embryos transferred because they were unwell with OHSS. Version 2: March 2008: VS / EB 2

The IVF Pathway HFEA Verified Success Rates up to second quarter 2014 HFEA Ranking of NHS Clinics: Pregnancy Rates per Cycle (IVF and ICSI) in women under 38 years (NHS and Private) patients)   HFEA CLINIC RANKING PREGNANCY RATES PER CYCLE (%) 12 Leeds Centre for Reproductive Medicine, Leeds 41.71% 32 James Cook University Hospital, Middlesbrough 35.89% 34 Hewitt Centre, Liverpool 35.59% 39 Hull IVF Unit 34.75% 40 The Gateshead Fertility Unit 34.65% 48 St Mary’s Hospital, Manchester 32.13% 66 Centre for Life, Newcastle 26.92% 68 Jessop Fertility, Sheffield 26.73% We are the top performing NHS provider in NofE Denominator ie out of 76 providers of IVF / ICSI / ET in UK (NHS & Private)= top 15% Version 2: March 2008: VS / EB 3

The IVF Pathway Time Lapse Imaging Incubators: 2 year data Clinical Pregnancy Rate Early Pregnancy Loss Rate Age (years) Age (years) Data for September 2013 – August 2015 In all age groups the pregnancy rate is higher in the women who used TLI For all women who used TLI, the miscarriage rate was lower, and this was statistically significant in women <38 years