Date of download: 7/10/2016 Copyright © The American College of Cardiology. All rights reserved. From: Crushed Prasugrel Tablets in Patients With STEMI.

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J Am Coll Cardiol. Published online September 28, doi: /j.jacc

Copyright © 2005 American Medical Association. All rights reserved.

Figure 4 Pharmacodynamic comparison of crushed versus integral

Nat. Rev. Cardiol. doi: /nrcardio

Nat. Rev. Cardiol. doi: /nrcardio

Nat. Rev. Cardiol. doi: /nrcardio

Glenn N. Levine et al. JACC 2011;58:e44-e122

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Date of download: 7/10/2016 Copyright © The American College of Cardiology. All rights reserved. From: Crushed Prasugrel Tablets in Patients With STEMI Undergoing Primary Percutaneous Coronary Intervention: The CRUSH Study J Am Coll Cardiol. 2016;67(17): doi: /j.jacc Trial Profile *Unknown at time of patient presentation. CABG = coronary artery by-pass graft; CAD = coronary artery disease; GP = glycoprotein; LD = loading dose; PCI = percutaneous coronary intervention; STEMI = ST-segment elevation myocardial infarction. Figure Legend:

Date of download: 7/10/2016 Copyright © The American College of Cardiology. All rights reserved. From: Crushed Prasugrel Tablets in Patients With STEMI Undergoing Primary Percutaneous Coronary Intervention: The CRUSH Study J Am Coll Cardiol. 2016;67(17): doi: /j.jacc Pharmacodynamic Assessment Following Administration of Whole Tablet Versus Crushed Tablet Prasugrel Loading Dose (A) P2Y12 reaction units (PRU) measured by the VerifyNow P2Y12 assay. (B) Platelet reactivity index (PRI) measured by the vasodilator stimulated phosphoprotein assay. *p > 0.1. Values are expressed as least-square means. Error bars indicate 95% confidence intervals. ANOVA = analysis of variance. Figure Legend:

Date of download: 7/10/2016 Copyright © The American College of Cardiology. All rights reserved. From: Crushed Prasugrel Tablets in Patients With STEMI Undergoing Primary Percutaneous Coronary Intervention: The CRUSH Study J Am Coll Cardiol. 2016;67(17): doi: /j.jacc Rates of High On-Treatment Platelet Reactivity Following Administration of Whole Tablet Versus Crushed Tablet Prasugrel Loading Dose (A) High on-treatment platelet reactivity (HPR) rates as assessed by the VerifyNow P2Y12 assay. (B) HPR rates as assessed by the vasodilator-stimulated phosphoprotein assay. Histograms represent rates. Figure Legend:

Date of download: 7/10/2016 Copyright © The American College of Cardiology. All rights reserved. From: Crushed Prasugrel Tablets in Patients With STEMI Undergoing Primary Percutaneous Coronary Intervention: The CRUSH Study J Am Coll Cardiol. 2016;67(17): doi: /j.jacc Pharmacokinetic Profile of Prasugrel’s Active Metabolite Following Administration of Whole Tablet Versus Crushed Tablet Prasugrel Loading Dose Values are expressed as means. Error bars indicate standard error. P-AM = prasugrel’s active metabolite. Figure Legend:

Date of download: 7/10/2016 Copyright © The American College of Cardiology. All rights reserved. From: Crushed Prasugrel Tablets in Patients With STEMI Undergoing Primary Percutaneous Coronary Intervention: The CRUSH Study J Am Coll Cardiol. 2016;67(17): doi: /j.jacc Crushed Prasugrel in STEMI The effect of crushing prasugrel on pharmacokinetic and pharmacodynamic profiles. STEMI = ST-segment elevation myocardial infarction. Figure Legend: