LYMPHOID TISSUE Objectives: بسم الله الرحمن الرحيم

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LYMPHOID TISSUE Objectives: بسم الله الرحمن الرحيم By the end of the lecture, the student should describe the microscopic structure of the following organs in correlation with their functions: 1- Lymph nodes. 2- Spleen. 3- Tonsils. 4- Thymus.

LYMPHOID TISSUE Lymphocyte

LYMPHOID TISSUE A) Diffuse lymphoid tissue B) Encapsulated lymphoid organs: 1- Lymph nodes. 2- Spleen. 3- Tonsils (are incompletely encapsulated) 4- Thymus. N.B. Both red bone marrow & Thymus are considered 1ry. Lymphoid organs.

LYMPH NODES (L.N.) Stroma: 1- Capsule 2- Trabeculae (septa) 3- Reticular C.T. Parenchyma: (lymphoid tissue + lymph sinuses) 1- Cortex 2- Paracortex 3- Medulla

1- Lymphatic nodules (follicles): a- 1ry: without germinal center 1. CORTEX OF L.N. 1- Lymphatic nodules (follicles): a- 1ry: without germinal center b- 2ry: with germinal center: Lighter 2- Cortical lymph sinuses.

2. PARACORTEX Of L.N. 3. MEDULLA OF L.N. It is the thymus-dependent zone of L.N. It is composed mostly of T-lymphocytes. 3. MEDULLA OF L.N. (1) Medullary cords: are formed mainly of lymphoid cells ( B & T lymphocytes, plasma cells, macrophages). (2) Medullary lymph sinuses. FUNCTIONS OF L.N. 1- Production of immunocompetent cells. 2- Filtration of lymph.

SPLEEN A. Stroma: 1- Capsule. 2- Trabeculae. 3- Reticular C.T. B. PARENCHYMA: (A) White pulp. (B) RED PULP. N.B. No cortex, no medulla.

FUNCTIONS OF SPLEEN 1- Filtration of blood. 2- Phagocytosis of old RBCs & old blood platelets & invading microorganisms. 3- Production & proliferation of immunocompetent B & T lymphocytes. 4- Production of antibodies.

Tonsils Palatine Tonsils. Pharyngeal Tonsil. Lingual Tonsils.

PALATINE TONSILS Structure: 1- Epithelium: 2- Tonsilar crypts. non-keratinized stratified squamous. 2- Tonsilar crypts. 3- Lymphatic nodules. 4- Capsule: partial. FUNCTION OF TONSILS Production of antibodies.

THYMUS Stroma: 1-Capsule 2-Interlobular trabeculae: incomplete B) Thymic lobule: 1-Cortex 2-Medulla

CORTEX OF THYMIC LOBULE A) It contains developing (immature) T- lymphocytes (thymocytes). 98% of thymocytes die? B) Epithelial reticular cells C) Macrophages. N.B. No lymphatic nodules No plasma cells No B-lymphocytes

MEDULLA OF THYMIC LOBULE 1-Hassall’s (thymic) corpuscles: -Concentrically arranged epithelial reticular cells in the medulla. 2- Mature small T lymphocytes 3- Macrophages. 4- Epithelial reticular cells. N.B. Medulla of adjacent thymic lobules are interconnected- Why? Incomplete trabeculae

FUNCTION OF THYMUS Maturation of T lymphocytes. (Immunoincompetent T cells →→→ Immunocompetent T cells).

General notes about thymus No lymphoid nodules No reticular fibers No sinuses or sinusoids