REVISION

يمكن الاستفادة من هذا العرض التقديمي في مراجعة ما يتعلق ب WBCs maturation & Leukemia هذا الجزء لا يشمل RBCs يمكن المراجعة ذاتيا عن طريق الضغط على زر العرض بحيث ستظهر الصورة بدون تعريف, وعلى الطالبة محاولة التعرف عليها وعند النقر على الماوس سيظهر تعريف الصورة.

DIFFERENT MYELOID STAGES

Charecteristics of granulocyte granules Charecteristics of granulocyte granules. The colour of the letters is the same as that of the granules and the backgroung the colour of cytoplasm of the cell the granules are most prominant in.

Pronormoblast

Auer rods in promyelocytes of M3

Toxic granulation of neutrophil

orthochromic normoblast

A- Pronormoblast B- polychromatic normoblast C- orthochromic normoblast

Promonocytes (with a single fissure in the nucleus)

b a A- neutrophilic metamyelocyte b- neutrophilic myelocyte

Promonocytes (with a single fissure in the nucleus)

b b c a A- Promonocyte B- orthochromic normoblast c- band neutrophil

Peroxidase negative , PAS positive blast cells cells of the different populations, lymphoblasts from L2 type

basophilicnormoblasts

b b b b c b a a b d b f e A-pronormoblast b- orthochromic normoblast C- neutrophilic myelocyte D- neutrophilic metamyelocyte E- band neutrophil F- segmented neutrophil

b a a a a b b A- Promonocyte B- myeloid cell (both are present in M4 leukemia b

a b b a- polychromatic normoblast (megaloblast) b- orthochromic normoblast

a b b a A- Promonocyte B- promyelocyte (M4 leukemia)

Different maturation stages of myeloid cell in M2 leukemia.

Pronormoblast

Different maturation stages of myeloid cell with M2 leukemia.

Myeloblasts from M1 or M0 Peroxidase will confirm diagnosis

Myeloblasts from M1 Auer rods confirm diagnosis of M1 not present in M0

basophilic myelocyte

Peroxidase negative , PAS positive blast cells Small cells of the same population, lymphoblasts from L1 type

Peroxidase negative , PAS positive blast cells Small cells of the same population, lymphoblasts from L1 type

Peroxidase negative , PAS positive blast cells cells of the different populations, lymphoblasts from L2 type

Monocytic precursors of M5 leukemia

Lymphoblasts of hairy cell leukemia (myelofibrosis)

Lymphoblasts of hairy cell leukemia (myelofibrosis)

Lymphoblasts of hairy cell leukemia (myelofibrosis)

Plasma cells of multiple myeloma (note the multinucleated cell)

PAS +ve lymphoblast from L3 leukemia

Plasma cells of multiple myeloma (note the multinucleated cell)

Plasma cells of multiple myeloma (note the multinucleated cell)

Peroxidase negative , PAS positive blast cells cells of the different populations, lymphoblasts from L2 type

Erythrophagocytosis

Erythrophagocytosis

LE cell

a c b e d d d d A- Eosinophilic myelocyte B- Promyelocyte C- Basophilic normoblast D- Polychromayic normoblast E- Orthochromic normoblast

Eosinophilic myelocyte

Basophilic metamyelocyte

Lymphoblasts of hairy cell leukemia (myelofibrosis) The red stain is ACP +ve hairy cell

Eosinophilic metamyelocyte

megakaryocyte

Segmented Basophil

Promyelocytes with auer rod bundles from M3

CD 41 +ve cells Megakaryoblast from M7 leukemia

megakaryoblast

pronormoblasts

Erythroid prcusors from M6 Leukemia

MPO stain Myeloblast from M1

Different myeloid stages from M2

Different myeloid stages from M2

Different myeloid stages from M2

Promyelocytes with auer rod bundles from M3

Different eythroid precursors in M6 leukemia

Non specific esterase +ve cells Monoblast From M5

PAS +ve lymphoblast from L1 leukemia

neutrophilic metamyelocyte and segmented neutrophil