DERM Azad Karim

INFECTIONS  Parvo B19:  “Slap Cheek”  Hydrops fetalis/ SC crisis  Scabies  Burrows/ linear rash  Tx w. Permethrin + wash everything  Impetigo:  GAS or S. aureus  PSGN (not rheumatic fever)  HPV  Strains 16/18 oncogenic  E6-> p53 & E7-> Rb  Koilocytes

Infections Cont.  Herpes:  Vesicles on Erythematous base  HSV (oral, genital, congenital)  VZV (chicken pox  Reactivates as Shingles)  Rx w. Acyclovir  Hand foot mouth disease  Coxsackie A16 (Coxsackie B causes?)  Symptomatic Tx  Tinea  Clear center w/ bumpy boarder  Most common cause is Trichophyton  Tx w. Azoles  Lyme disease  Erythema migrans  Cardiac block  Tx w. Doxycycline (except kids <8yo WHY?) Site of this patient’s virus prior to lesion?

Immunological  Bullous Pemphigoid  Anti-Hemidesmosome IgG (T2 HS)  Same pathophys as Goodpasture (why?)  Pemphigus vulgaris  Anti-desmoglein IgG (T2 HS)  Positive Nikolsky’s sign & Oral Blisters  Contact dermatitis:  T4 Hypersensitivity – T cell mediated  Nickel or Poison ivy  Treatment: Steroids (longterm complication?)  What test has the same pg as Poison ivy?  Dermatitis herpitaformis  Celiac disease association  IgA deposition

Cancer  Squamous Cell  Precursor: Actinic Keratosis  Keratin pearls  Lower lip  Basal Cell  Telangiectasia  Upper Lip  Melanoma  ABCDEs  S-100 (Neural Crest origin)  Schwann cells/ melanocytes

CASES  14 yo WF complaining of fatigue and facial rash. Dx? Herald patch Gottron’s papules PE reveals rash on torso and dorsum of the fingers (MP joints)? Afebrile and normal labs Diagnosis: Dermatomyositis. Pt has increased risk of? Ovarian Cancer (IDK why) and other malignancies  10 yo AAM presents with rash throughout his back that was proceeded by a spot on his arm. Tx with Anti-histamines & Steroids Initial spot said to be “salmon colored” Rash is bilateral on his torso and goes up his back “Christmas tree appearance” Diagnosis: Pityriasis Rosea