Screening Hemostasis Assays CBC,PBS Thrombocytopenia, Thrombocytosis, Giant P PT Vit K deficiency,Liver d. DIC, VII,V, IX deficiency and Factor inhibitor.

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Presentation transcript:

Screening Hemostasis Assays CBC,PBS Thrombocytopenia, Thrombocytosis, Giant P PT Vit K deficiency,Liver d. DIC, VII,V, IX deficiency and Factor inhibitor. PTT Heparin, DIC, Lupus anticoagulant, vWD XI, IX,V, X, XII, HMWK, PK, factor inhibitor. TT Heparin, DIC, Hypofibrinogenemia, Dysfibrongenemia Bleedig T. Aspirin, Thrombocytopenia, vWD, Storage pool disease Mixing Study Abnormal clotting time corrects w ith a deficiency dose not correct with an inhibitor.

Endothelial cell Coagulation Properties Procoagulant Anti-Coagulant Collagen Factor VIII Fibronectin Integrins P-endothelial cell adhesion molecule-1 Selectin-E Selectin-P Von Willebrand f. Vasoconstriction Vasodilation ADP ase Heparin Sulfate Nitric oxide Prostacyclin Thrombomodulin Tissue factor pathway inhibitor Tissue Plasminogen activator