1. Dubravka Šipuš, 2nd year 2013/2014 Mentor: A. Žmegač Horvat

2.  Hemostasis – prevention of blood loss  Mechanisms: 1) Vascular constriction 2) Formation of a platelet plug 3) Formation of a blood clot 4) Growth of fibrous tissue

3.  Fast process  Procoagulants and anticoagulants  Complex cascade of chemical reactions  Blood coagulation factors

5.  Formation of prothrombin activator  Extrinsic pathway  Intrinsic pathway

9.  Endothelial surface factors (smoothness, glycocalyx, thrombomodulin)  Antithrombin III - heparin cofactor  Coumarin (warfarin)  Citrate ion, oxalate

10.  Vitamin K deficiency  Diseases of the liver  Hemophilia  Thrombocytopenia

11.  Hemophilia A - abnormality or deficiency of Factor VIII  Recessive sex-linked, X chromosome disorder

12.  Guyton, Hall: Textbook of Medical Physiology