Protein Structure and Function. Proteins are organic compounds made from amino acids held together by peptide bonds.

Slides:

Advertisements

Similar presentations

Proteins from Amino Acids

Advertisements

Tertiary Structure of Proteins The tertiary structure defines the specific overall 3-D shape of the protein Tertiary structure is based on various types.

Chemistry: An Introduction to General, Organic, and Biological Chemistry, Twelfth Edition© 2015 Pearson Education, Inc Proteins: Secondary, Tertiary,

Chapter 16 Amino Acids, Proteins, and Enzymes

Proteins & Nucleic Acids Images taken without permission from

19.6 Primary Structure The primary structure of a protein is the sequence of amino acids in the peptide chain Protein backbone Ala-Leu-Cys-Met.

Protein Structure: Tertiary and Quaternary Structure 20.7 Protein Hydrolysis and Denaturation Chapter 20 Amino Acids and Proteins.

Polypeptides – a quick review A protein is a polymer consisting of several amino acids (a polypeptide) Each protein has a unique 3-D shape or Conformation.

1. Primary Structure: Polypeptide chain Polypeptide chain Amino acid monomers Peptide linkages Figure 3.6 The Four Levels of Protein Structure.

Proteins Structures Primary Structure.

Amino acid side chains stabilise the enzyme shape.

AMINO ACIDS AND PROTEINS

Daily Starter  Explain how a peptide bond is formed. (What is the reaction called and how does it happen?)

Proteins most diverse and important molecules in most diverse and important molecules in living organisms living organisms coded for by DNA coded for by.

Diverse Macromolecules. V. proteins are macromolecules that are polymers formed from amino acids monomers A. proteins have great structural diversity.

Proteins. You need to know that: Proteins have a variety of functions within all living organisms. The general structure of an amino acid Condensation.

Supersecondary structures. Supersecondary structures motifs motifs or folds, are particularly stable arrangements of several elements of the secondary.

1 Amide Bond Formation Amide bonds form upon reaction of carboxylic acids with ammonia, primary amines or secondary amines. When amide bonds form between.

Levels of Protein Structure

 Proteins have many different functions in the body  Structure – proteins help provide structure and support, make up muscles and bones.

3.2 Proteins Mini Lecture Radjewski. Major functions of proteins: Enzymes—catalytic proteins Defensive proteins (e.g., antibodies) Hormonal and regulatory.

Welcome to Human Biochemistry! Jim Keck, Biomolecular Chemistry - Protein biochemist Contact info: (office in

PROTEINS PROTEINS Levels of Protein Structure.

A protein’s function depends on its specific conformation (shape) A functional proteins consists of one or more polypeptides that have been precisely twisted,

Lecture 1: Fundamentals of Protein Structure

Proteins I BCH 302 [practical].

1 Proteins Protein functions include: 1. enzyme catalysts 2. defense 3. transport 4. support 5. motion 6. regulation 7. storage Chapter 3- part 2.

Proteins. Slide 2 of 19 Proteins  Polymers composed of amino acids  Protein = Polypeptide (polymer)  Monomer = Amino acids  Peptide bonds  Amino.

Proteins Pgs Pgs Allosteric Enzymes  Allosteric enzymes have 2 sites. Active site of the enzyme Additional site where another substance.

PROTEIN FUNCTIONS. PROTEIN FUNCTIONS (continued)

BIOLOGICALLY IMPORTANT MACROMOLECULES PROTEINS. A very diverse group of macromolecules characterized by their functions: - Catalysts - Structural Support.

Amino Acids & Proteins The Molecules in Cells Ch 3.

General, Organic, and Biological Chemistry Copyright © 2010 Pearson Education, Inc Protein Hydrolysis and Denaturation Chapter 19 Amino Acids and.

Protein Structure Primary - sequence of amino acids Secondary – folding into pleated sheets or alpha helix Tertiary – 3-D structure, completely folded.

Proteins Biochemistry Unit 1. What You Need to Know! How to recognize protein by its structural formula The cellular function of proteins The four structural.

Proteins pp Proteins Proteins are used for: Amino acids.

Proteins: multipurpose molecules

Proteins Structure and Function. PROTEINS Proteins are essential to the structures and activities of life...

PROTEINS L3 BIOLOGY. FACTS ABOUT PROTEINS: Contain the elements Carbon, Hydrogen, Oxygen, and NITROGEN Polymer is formed using 20 different amino acids.

Proteins  Are the most diverse biomolecules. They make up muscles, skin, hair, enzymes, hormones, hemoglobin, and antibodies.  The basic structure unit.

Proteins. Protein (from the Greek protas meaning "of primary importance") is a complex, high-molecular-weight organic compound that consists of amino.

Qualitative Tests for Proteins

Chemistry: An Introduction to General, Organic, and Biological Chemistry, Eleventh Edition Copyright © 2012 by Pearson Education, Inc. Chapter 16 Amino.

WARM UP 1/29/16 1. Name the six functional groups. 2. Draw the STRUCTURAL formula for each one.

PROTEINS Proteins Composed mainly of –Carbon –Hydrogen –Nitrogen.

1 Proteins Continued –Tertiary Structure: refers to the overall 3-D shape of a protein produced from bending and folding stabilized by interactions between.

Chapter 5 Proteins.

19.6 Protein Hydrolysis and Denaturation

Chapter 6: Proteins and Amino Acids

Protein Structure.

Chapter 6: Proteins and Amino Acids

Proteins Section 3.4.

Proteins Basic structure of an amino acid

See Page 563 Essential amino acids must be obtained from the diet.

PROTEINS and ENZYMES!.

The Chemistry of Life Proteins

Diverse Macromolecules

Study Question: What are enzymes?

Protein Structure Chapter 14.

Proteins C, H, N, O, S 50% of the Dry Weight of Living Organisms

Protein (cont.) Definition

Four Levels of Protein Structure

Presentation transcript:

Protein Structure and Function

Proteins are organic compounds made from amino acids held together by peptide bonds.

Functions of proteins Enzymes: Accelerate biochemical reactions Structural:Form biological structures Transport:Carry biochemically important substances Defense:Protect the body from foreign invaders

Primary structure = order of amino acids in the protein chain

Primary sequence reveals important clues about a protein small hydrophobic large hydrophobic polar positive charge negative charge Evolution conserves amino acids that are important to protein structure and function across species. Sequence comparison of multiple “homologs” of a particular protein reveals highly conserved regions that are important for function. Clusters of conserved residues are called “motifs” -- motifs carry out a particular function or form a particular structure that is important for the conserved protein. motif

Secondary structure = local folding of residues into regular patterns

Tertiary structure = global folding of a protein chain

Quaternary structure = Higher-order assembly of proteins

Denaturing of proteins involves the disruption and possible destruction of both the secondary and tertiary structures

What can denature (break down) proteins? Heat (cooking) Alcohol Disrupts Hydrogen Bonding Acids and Bases Disrupt Salt Bridges Heavy Metal Salts