30 years as a biotechnological company to research to develop to produce to commercialize Biotechnological process for HEALTH

strong bet in RESEARCH Projects Patents Publicactions Implantation of new technologies

NO COMMERCIAL ACTIVITY

COMMERCIAL PRODUCT  Equipments,  Diversification,  R&D Contracts FINANCIAL CRASH OF THE MAIN SHAREHOLDER 1992 NO COMMERCIAL ACTIVITY

NEW STRATEG COMMERCIAL RANGE DEVELOPMENT ? CAPITAL 1 COMMERCIAL PRODUCT  Equipments,  Diversification,  R&D Contracts NO COMMERCIAL ACTIVITY

COMMERCIAL ACTIVITY 40 Mill de Pts 5,1 Mill de € 100% PRIVATE

Private capital 100 %

Tools for reaching our objectives

Toos for reaching our objectives technologies know how human team

Human team 42 people universitary degree (biologists, veterinarian, biochemist) Technicians Assistants External Service Administration

Immunoassays PCR Mab development Protein expression systems Transcriptonic Phage-display thecnologies

Immunoassays PCR Mab development Protein expression systems Transcriptómic Phage-display

Immunoassayss based on the specific binding between antígen and antibody ELISAs Immunochromatografic test

Immunoassays PCR Mab development Protein expression systems Transcriptómic Phage-display

PCR techniques based on the replication of specific sequences of nucleic acids x2x2 x2x2 x2x2 x2x2 x2x2 x2x2 x2x2 x2x2 x2x2

PCR

Immunoassays PCR Mab development Protein expression systems Transcriptómic Phage-display

Monoclonal Antibodies Development Originate biological systems able to produce an antibody (immunoglobulin) specific for a single antigenic determinant TRADITIONAL METHODNEW TECHNOLOGY + development production PHAGE DISPLAY

Immunoassays PCR MAb development Proteins expression system Transcriptomic Phage-display

Proteins expression system Use of the cellular system to synthesize peptides or proteins of interest

Proteins expression system Use of the cellular system to synthesize peptides or proteins of interest

Proteins expression system PROCARIOTIC SYSTEM EUCARIOTIC SYSTEM

Immunoassays PCR MAb development Proteins expression system Transcriptomic Phage-display

Transcriptomic Evaluation of the expression level of particular genes by studding the mRNA present in the cells. Arrays Bioinformatics analysis

Immunoassays PCR MAb development Proteins expression system Transcriptomic Phage-display

Allows knowing and selecting sequences codifying for biologically “useful” peptides or proteins. Uses the ability of some phages to expose at their capside proteins or peptides codified by genes artificially inserted in their genome. PHAGE

Phage-display PHAGO A gene from a library of genes

Phage-display PHAGO each phage receives a different and unique gene Each phage will expose at its capside one kind of exogenous protein or peptide

PHAGE Phage-display In every phage, there is a coexistence between the gene and the protein codified by this gene.

PHAGE Phage-display If we are able to select the phages through the activity of the protein they express …. … we have selected the gene which codify for this protein!

know how

79 Publications 62 Patents 36 Proyects

Our OBJETIVE is still the same

OBJETIVE research development production commercialization Biotechnology procedures applied to HEALTH animal plants human food

OBJETIVE research development production commercialization Biotechnology procedures applied to HEALTH animal plants human food

R esearch + D evelopment R&D

DUAL Strategy SHORT-TERM Diagnostic Procedures Short periods for registration Using industrial structure = very quickly in the market COMMERCIAL ACTIVITY LONG-TERM Vaccines and therapeutics Long periods for registration Require a bigger industrial structure to be in the market. PATENTS LICENSE

R & D Short Term R&D, today on market Actual product catalogue:

Veterinarian diagnosis 8 animal species 61 pathologies 105 references R & D Short Term R&D, today on market Actual product catalogue:

R & D Short Term R&D, today on market Actual product catalogue:

R & D Short Term R&D, today on market Actual product catalogue: Plant diseases diagnosis Food safety Human diagnosis

R & D Short Term R&D, today on market Actual product catalogue:

R & D Short Term R&D, today on market Actual product catalogue: Technologies Elisas Inmunochromatografy PCRs

R & D LongTerm R&D, actual ID projects

R & D Long Term R&D: actual R&D projects We are a small company, but we have surrounded ourselves by great institutions in many of our projects: ID-DLO (NL) SVIV (DK) Inst. PASTEUR (FR) OXFORD Univ. (UK)

R & D Long Term R&D: actual R&D projects

R & D Long Term R&D: actual R&D projects VI Programa Marco Immune Response to respiratory virus infections and vaccination in elderly.

New tools and approaches to control Porcine Reproductive and Respiratory Syndrome in the EU and ASIA (PRSSCon)” Development of multivalent vaccines for BTV, EHDV and AHSV (ORVIVAC) R & D Long Term R&D: actual R&D projects VII Programa Marco Evaluating and controlling the risk of African Swine Fever in the EU (ASFRisk) Strategies for the eradication of Bovine Tuberculosis. (TB-Step)

R & D Long Term R&D: actual R&D projects

R & D Long Term R&D: actual R&D projects Research and Development of new technologies for therapeutic applications and diagnosis for Cancer Cenit porject

R & D Long Term R&D: actual R&D projects Biomarkers searching for colon, lung, ovary and melanoma cancers and development of tests for diagnosis/prognosis

R & D Long Term R&D: actual R&D projects Our partners in the project:

R & D Long Term R&D: actual R&D projects Technologies and phases of the project in which we participated: Levels of genic expression analysis for biomarkers selection Specific antibodies development to the selected biomarkers MONOCLONAL ANTIBODIES TRANSCRIPTONICS ASSAYS DEVELOPMENT Desing and completion of detection tests (ELISA DAS, IC)

M anufacturing & S ales M & S

manufacturing under rigorous QC rules and controls

M & S Facilities Reagents preparation 01

M & S Facilities Coating plates 02

M & S Facilities Coating plates 02

M & S Facilities Coating plates 02

M & S Facilities Coating plates 02

M & S Facilities Packaging and storage 03

M & S Facilities Packaging of kits 04

M & S Products distribution

M & S Products distribution Large distribution net world wide 3956 distributorspresents in countries

M & S Products distribution NARVAC 2 CL TSENG LIFE STAR MICRONIC AGROVET SCIENTIFIC LINE MEGAPHARMA TIN HANG

M & S Products distribution NOACK BIOGNOSIS PLATERO QEFII DIACHEL PRIONICS AGROLABO TRASCO INGENASA

still growing...