New Science Opportunities with X-ray Free Electron Lasers (FEL) What are X-ray FELs Current UK position Science with X-ray FELs Developing a national capability Jon Marangos Imperial College Physics Department

X-ray FEL Using Coherent High Brightness X-rays From SASE (Self Amplified Spontaneous Emission) Undulator Input Low emittance, relativisitic electron bunch 5 – 15 GeV E/E < 10-3 Output High brightness, short pulse of coherent soft to hard X-rays Pulses < 10 fs Narrow spectral bandwidth Wide tuning range with multi-keV photons for structural methods (e.g. XAS, IXS, X-ray diffraction) Exceptional available brightness High peak flux on target 2 High Photon Number Short pulses Unmatched brilliance Nine orders of magnitude

X-ray SASE Free Electron Lasers LCLS Euro XFEL Hard X-ray projects SLS FEL KOREA LINAC COHERENT LIGHT SOURCE LCLS 2009 2017 2012 European XFEL Facility SACLA SPring-8 Compact SASE Source

New High Repetition Rate Superconducting Machines Will Be Even More Transformative XFEL in Hamburg: A High Rep Rate SASE Machine ~ 10,000 shots per second LCLS II Existing 120 Hz machine to 20 keV + High rep-rate (100 kHz to 1 MHz) 250 eV – 5 keV machine JPM & RW led UK NLS project with a CDR published in June 2010. Passed peer review and remains one of the UK’s highest priority large capital scientific projects awaiting funding approval. Ongoing discussion on UK FEL strategy

The Current UK Landscape The current UK XFEL community is small but very effective – 20 PIs, and ~80 active researchers based at 12 different institutions. They have been using the facilities at LCLS, FLASH, SACLA, and FERMI to investigate: protein structural dynamics nanocrystal protein structures matter at extreme conditions (solids and plasmas) fast modifications to metals time resolution of prototypical photo-chemical reactions ultrafast electron dynamics in molecules

Current UK position STFC: The UK has committed to becoming a full member of the European XFEL facility (now under construction near Hamburg, Germany). A review has been undertaken that will provide the framework for making decisions on any further FEL commitments that the UK may make. UK is part of the Helmholtz International Beamline for Extreme Fields (HIBEF) and the Serial Femtosecond Crystallography (SFX) beamline consortia at XFEL.EU. UK’s contribution to HIBEF is the DiPOLE laser, funded by STFC and EPSRC at ~£4M each, with its operation costs yet to be confirmed. UK will contribute £5.6M  to the SFX beamline, through BBSRC, MRC and the Wellcome Trust.

In was recognised that STFC needs to develop a coherent strategy for facility provision – including FELs Set up a review panel that: identified key science challenges that would benefit from access to a FEL facility considered the ability of existing and near-future FEL facilities to address these science challenges. proposed a 7 year strategy for FEL access, UK FEL facility provision, community development, and underpinning technology/skills. Proposed a 15 – 20 year vision for UK FEL science Courtesy of Malcolm McMahon

A UK FEL Strategy: UK FEL Forum Position Doing nothing is not an option. Support and grow the FEL science community so that UK can be competitive across broad areas of science Invest in current and near-future facilities internationally Attract new researchers via studentships, travel grants, fellowship calls, and a cross-RC CDT Targeted project funding from the relevant RCs for travel, equipment and postdocs Re-engaging communities associated with previous proposals for UK FEL facilities.

A UK FEL Strategy: UK FEL Forum Position Meeting the UK’s long term needs may require constructing an X-ray FEL facility in the UK Even if the UK maximises its opportunities for access elsewhere, the UK’s demand may exceed this level in <10 years In the long term, the UK’s capacity requirements may be best served by constructing a UK-XFEL facility To address the majority of key science challenges, a UK facility would need to deliver hard X-rays. Ideally it would have a high (MHz) repetition rate. However, this is likely to be costly as a national facility. A compromise specification may need to be defined to fit UK science.

Frontiers In Science for the Mid-21st Century Include Understanding the structural dynamics of physical, chemical and biochemical processes at the atomic scale: Making molecular movies Controlling quantum scale processes in matter: Directing electronic dynamics, information and energy flow Sub-nanometre scale imaging of arbitrary objects in their native state: Capturing the structure of an individual living cell or nanostructure

X-ray FELs are uniquely suited The science calls for: ULTRAFAST HIGH BRIGHTNESS HIGH REP-RATE X-RAY photon sources. X-ray FELs are uniquely suited

Current X-ray FEL Science Highlights Structural dynamics Matter at extreme conditions Nanostructure imaging Serial nano-crystallography

Incisive structural probes such as time resolved X-ray spectroscopy and diffraction are key to this science UV/IR/THz pump (including optimally shaped control pulses) Ultrafast X-ray probes e.g. XAS, XPS,RIXS, XRD to give instantaneous structure during chemical reactions and condensed matter changes Capture time evolution: Structure Electronic states Spin states

Time Resolving Chemical Reactions Catalysis and chemistry in solution phase: “Orbital-specific mapping of the ligand exchange dynamics of Fe(CO)5 in solution” Nature 520, 78 (2015) “Tracking excited-state charge and spin dynamics in iron coordination complexes” Nature 509, 345 (2014) Time resolving surface catalysis Science 347,978 (2015) Fundamental events in chemistry: “Ultrafast X-ray Auger probing of photoexcited molecular dynamics” Nature Comm., 10, 1038 (2014) “X-ray induced ultrafast isomerization acetylene - vinyldiene” Nature Comm. , 6, 8199 (2015)

Time resolving phase changes in strongly correlated materials Light control of quantum solids (THz pump – X-ray probe): Field induced high temperature superconductivity? Femtosecond dynamics of long range order: coupling of; lattice, spin, charge and orbitals

Matter at extreme conditions Measuring highly transient states: “Direct observation of melting in shock compressed bismuth with fs X-ray diffraction PRL 115, 095701 (2015) Probing laser generated warm dense matter: “Ultra-bright X-ray laser scattering for dynamic Warm dense matter physics” Nature Phot. 10, 1038 (2015) Probing hot dense matter: Nature Communications 6, 6397 (2015) Phys. Rev. Lett. 114, 015003 (2015) Nature Communications 5, 3313 (2014) Phys. Rev. Lett. 109, 245003 (2012) Phys. Rev. Lett. 109, 065002 (2012) Nature 482, 59 (2012)

Imaging the dynamics of individual nanostructures “Imaging transient melting of a single gold nanocrystal” PNAS 112, 7444 (2015) “Ultrafast 3-D imaging of lattice dynamics individual gold nanocrystals” Science 341, 6141 (2013) Nanoscopic imaging single biological organisms: “3-D reconstruction of the giant mimivirus particle with X-ray FEL” PRL, 114, 098102 (2015) “High throughput imaging of heterogeneous cell organelles with an X-ray FEL” Nature Phot. 8, 943 (2014) “Imaging single cells in a stream of live cyanobacteria… “ Nature Comm. (2015)

“Diffract and Destroy” possible if pulse very short and very bright Non-crystal samples destroyed before signal enough to image “Diffract and Destroy” possible if pulse very short and very bright

“Diffract and Destroy” has been applied to protein nanocrystals with 20fs X-ray pulses first demonstrated 2011 Kuptiz et al, Nature 513, 261 (2014)

Serial nanocrystallography is a promising development in structural biology

Applications to medicine TbCatB protein of the Trypanosoma brucei protozoan – critical agent in sleeping sickness Applications to neuroscience “Architecture of the synaptotagnmin- SNARE machinery for neuronal exocytosis” Nature 525, 62 (2015)

What do we need if we build a national facility to do this science? Broad photon tuning capability: photons from 100 eV to > 10 keV Versatile configuration: Synchronised laser sources, X-ray double pulse, seeded High peak brightness: >1012 photons pulse for “diffract and destroy” of single molecules High repetition rate: ARPES, RIXS etc. demand low intensity on target so need to have many pulses for SNR

What will we need to do to enable this? Develop a fully coordinated FEL R&D programme, building upon existing expertise in the following areas: accelerators; detectors; lasers and auxiliary light sources; diagnostics; sample environment and target delivery; simulation, control, data acquisition, data analysis, and storage.

To build a uniquely capable facility Need to overcome existing limits on pulse synchronization, coherence and pulse shape Can we develop a high rep-rate hard X-ray machine cost effectively? e.g. taking lessons from compact FEL projects like SACLA and Swiss FEL and adopting new technologies like super-conducting undulators

SASE: Wavelength Fluctuation and Temporal Jitter Temporal (+/- 100 fs) jitter inhibits: Synchronisation with external sources High temporal resolution measurements Quantitative non-linear interaction studies Wavelength fluctuation inhibits: X-ray spectroscopy Inelastic scattering - Chemically sensitive CDI Ultrafast structural dynamic measurements at the femtosecond timescale need to overcome these limitations

Atomic Inversion Laser Rohringer, N. et al. Nature 481, 488–491 (2012). Results in a fixed wavelength but hard to do……..

Injection Seeding courtesy of Fulvio Parmigiani Not viable for hard X-rays…..

Self Seeding: Eliminates Wavelength Jitter courtesy of Jerry Hastings Promising and fixes wavelength jitter, but not temporal jitter…….

Time Stamping Courtesy of Ryan Coffee X-ray gated reflectivity Using chirped pulse for single shot timing measurement – Sub 20fs resolution demonstrated Combined with self seeding this might just do, but still need higher rep-rate to overcome fluctuations (in self seeding spectral fluctuations transferred to intensity fluctuation)….

X-ray FEL Measurement of Few Femtosecond Electron Dynamics LCLS LCLS with “low bunch charge” operation ~ 3 fs X-ray pulses are generated with ~ 1011 photons/pulse Several options are currently used at LCLS for few-fs resolved pump - probe X-ray Split and delay Two-pulse generation at single frequency Two-pulse / two-colour generation XFEL SACLA

Two bunch mode XTCAV After undulator Slot 1 Electron current time Bunch 1 Bunch 2 Slot 1 Slot 2 X-ray power After undulator Electron current τ From Marinelli et al Nature Communications (2015)

What do we need if we build a national facility to do future science? Laser-e-beam modulation: Slicing and seeding schemes to get ~ 1 fs level laser-X-ray synchronization – structural dynamics Attosecond pulses: Push the limits on pulse duration in two-pulse mode towards 100 as – electron dynamics Multi-colour operation: Synchronised X-ray pulses of very different and tuneable photon energy would be revolutionary – multi-dimensional spectroscopy for structural and electron dynamics Synchronised e-beam: Relativistic electron beam + XFEL pulse experiments would be a unique capability- radiobiology and structural dynamics

Thank you for your attention