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The Role of Nitric Oxide Synthase and Heme Oxygenase in the Protective Effect of Hypothermia in Ischemia- Reperfusion Injury by Russell Ward, Nicholas.

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Presentation on theme: "The Role of Nitric Oxide Synthase and Heme Oxygenase in the Protective Effect of Hypothermia in Ischemia- Reperfusion Injury by Russell Ward, Nicholas."— Presentation transcript:

1 The Role of Nitric Oxide Synthase and Heme Oxygenase in the Protective Effect of Hypothermia in Ischemia- Reperfusion Injury by Russell Ward, Nicholas Souder, Daniel Stahl, Felicia Hunter, Robert Probe, Christopher Chaput, and Ed Childs J Bone Joint Surg Am Volume 91(11):2637-2645 November 1, 2009 ©2009 by The Journal of Bone and Joint Surgery, Inc.

2 Line drawing depicting the experimental layout. Russell Ward et al. J Bone Joint Surg Am 2009;91:2637- 2645 ©2009 by The Journal of Bone and Joint Surgery, Inc.

3 Representative fluorescence microscopy images for each of the experimental groups at baseline, reperfusion time of zero minutes (Rep 0), and reperfusion time of sixty minutes (Rep 60). Russell Ward et al. J Bone Joint Surg Am 2009;91:2637- 2645 ©2009 by The Journal of Bone and Joint Surgery, Inc.

4 Graph showing the change in fluorescence intensity ratio (permeability ratio) at baseline and reperfusion times of zero to sixty minutes for the sham, warm ischemia-reperfusion (Warm I/R), and cold ischemia-reperfusion (Cold I/R) groups. Russell Ward et al. J Bone Joint Surg Am 2009;91:2637- 2645 ©2009 by The Journal of Bone and Joint Surgery, Inc.

5 Graph showing the change in fluorescence intensity ratio (permeability ratio) at baseline and at reperfusion times of zero to sixty minutes for groups given inhibitors of HO and NOS in comparison with the sham, warm ischemia-reperfusion (Warm I/R), and cold... Russell Ward et al. J Bone Joint Surg Am 2009;91:2637- 2645 ©2009 by The Journal of Bone and Joint Surgery, Inc.

6 Russell Ward et al. J Bone Joint Surg Am 2009;91:2637- 2645 ©2009 by The Journal of Bone and Joint Surgery, Inc.

7 Russell Ward et al. J Bone Joint Surg Am 2009;91:2637- 2645 ©2009 by The Journal of Bone and Joint Surgery, Inc.

8 Russell Ward et al. J Bone Joint Surg Am 2009;91:2637- 2645 ©2009 by The Journal of Bone and Joint Surgery, Inc.

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