1. microangiopathic hemolytic anemia

3. TTP

4. reticulocytes

5. Polychromasia

6. Autoimmune hemolytic anemia

7. Target Cells Increased surface to volume ratio Actually shaped like a bell (3D) Target cells are always hypochromic Excess membrane cholesterol and phospholipid Decreased osmotic fragility

8. Hemoglobin C disease Liver disease Iron deficiency Any hemoglobin abnormality Post splenectomy Target Cells

9. Target Cells (Codocytes)

10. Target Cells

11. 10 y/o boy of Italian descent Diagnosis : Beta thalassemia major Homozygous beta 0 thalassemia Comment : beta 0 = beta gene producing no beta chains no beta chains and hence no Hb A. untreated he has about 95% Hb F (remainder being Hb A 2 ) Treatment : Transfusion to maintain hemoglobin level; Chelation therapy to remove excess iron present due to hemolysis and transfusions. Bone marrow transplantation is treatment of choice

12. Case 2 Howell Jolly Body Sickle cell Erythroblast

13. Sickle cells (Drepanocytes)

14. Sickle Cells