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The Exposure-Dependent Effects of Aged Secondhand Smoke on Endothelial Function Paul F. Frey, MD, MPH; Peter Ganz, MD; Priscilla Y. Hsue, MD; Neal L. Benowitz,

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Presentation on theme: "The Exposure-Dependent Effects of Aged Secondhand Smoke on Endothelial Function Paul F. Frey, MD, MPH; Peter Ganz, MD; Priscilla Y. Hsue, MD; Neal L. Benowitz,"— Presentation transcript:

1 The Exposure-Dependent Effects of Aged Secondhand Smoke on Endothelial Function Paul F. Frey, MD, MPH; Peter Ganz, MD; Priscilla Y. Hsue, MD; Neal L. Benowitz, MD; Stanton A. Glantz, PhD; John R. Balmes, MD; Suzaynn F. Schick, PhD

2 Disclosure  Dr. Benowitz: paid consultant to pharmaceutical companies that are developing or market smoking cessation medications; has been a paid expert witness in litigation against tobacco companies.

3 Objectives  This study was conducted to investigate whether exposure to a range of relatively low concentrations of aged secondhand smoke (SHS), similar to those encountered commonly in the community, would impair endothelial function in a concentration-dependent manner. J Am Coll Cardiol 2012;59:1908-13

4 Background  Exposure to SHS impairs endothelial function in humans.  The concentration-dependent relationship for aged SHS effects on endothelial function after an exposure of short duration is unknown. J Am Coll Cardiol 2012;59:1908-13

5 Methods  We exposed 33 healthy nonsmokers to one of two low levels of aged secondhand smoke or to conditioned filtered air for 30 minutes.  The primary endpoint was change in maximal percent brachial artery flow- mediated dilation (% FMDmax) after exposure. J Am Coll Cardiol 2012;59:1908-13

6 Results  In a linear regression model for each increase in SHS exposure by 100 μg/m 3 respirable suspended particles (RSP), the absolute % FMDmax was reduced by 0.67%.  We did not find evidence of a threshold for the effect of SHS on FMD. J Am Coll Cardiol 2012;59:1908-13

7 Absolute Change in %FMDmax (post-exposure minus pre-exposure) vs. Dose of SHS with Linear Regression Line J Am Coll Cardiol 2012;59:1908-13

8 Relative Change in %FMDmax (post-exposure minus pre-exposure) in Percent vs. Dose of SHS with Linear Regression Line J Am Coll Cardiol 2012;59:1908-13

9 Conclusions  Short-term exposure to real-world levels of aged SHS for 30 minutes resulted in a concentration-dependent decrease in endothelial function as measured by flow-mediated dilation. J Am Coll Cardiol 2012;59:1908-13

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