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Supplemental Fig. 1 100  m B 50  m A. IL-1  secretion (pg/well) Y27632 Z-YVAD Asbestos Control Y27632 Z-YVAD CNT Control Y27632 Z-YVAD LPS Control.

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Presentation on theme: "Supplemental Fig. 1 100  m B 50  m A. IL-1  secretion (pg/well) Y27632 Z-YVAD Asbestos Control Y27632 Z-YVAD CNT Control Y27632 Z-YVAD LPS Control."— Presentation transcript:

1 Supplemental Fig. 1 100  m B 50  m A

2 IL-1  secretion (pg/well) Y27632 Z-YVAD Asbestos Control Y27632 Z-YVAD CNT Control Y27632 Z-YVAD LPS Control 0 10 20 30 40 50 60 CNTLPSAsbestos * * * # # # # # Supplemental Fig. 2

3 0 sec20 sec 1 min2 min Supplemental Fig. 3A

4 Supplemental Fig. 3B 0 100 200 300 400 500 600 700 LPS priming Control no treatment Y27632 LPS0 sec 20 sec 1 min 2 min IL-1  secretion (pg/well) MSU

5 ForwardReverse ROCK1S1UCAGUCAGAAUUCACAGCU UGCUAA UUAGCAAGCUGUGAAUUC UGACUGA S2GACAGAUGCGGGAGCUAC AAGAUCA UGAUCUUGUAGCUCCCGC AUCUGUC S3GCAUUUGGAGAAGUUCAA UUGGUAA UUACCAAUUGAACUUCUC CAAAUGC ROCK2S4GAAGCAGCUAUUAACAGA AAGAACA UGUUCUUUCUGUUAAUAG CUGCUUC S5CCGUUGCCAUAUUAAGUG UCAUAAA UUUAUGACACUUAAUAUG GCAACGG S6GGAGGAGAUUAUAGCACC UUGCAAA UUUGCAAGGUGCUAUAAU CUCCUCC Supplemental Fig. 4A

6 ROCK1 siRNAROCK2 siRNA Control siRNA ROCK1 ROCK2 Control S1S4S3S5S6 S1 S2 Supplemental Fig. 4B

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