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Supplemental Figure 1 A No. at risk T3 530 483 304 185 50 T2 559 545 373 228 76 T1 540 532 375 208 64

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Supplemental Figure 1 B No. at risk T3 530 499 325 196 52 T2 559 550 381 232 76 T1 540 535 380 209 64

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Supplemental Figure 1 C No. at risk T3 532 504 326 194 45 T2 563 552 382 228 76 T1 541 534 379 209 63

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D Supplemental Figure 1 No. at risk T3 530 488 316 189 49 T2 559 543 378 230 75 T1 540 529 379 208 63

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E No. at risk T3 530 488 316 190 49 T2 559 544 378 230 76 T1 540 529 378 208 64 Supplemental Figure 1

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F No. at risk T3 532 466 299 176 41 T2 563 509 347 201 63 T1 541 488 335 182 52 Supplemental Figure 1

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G No. at risk T3 532 466 301 175 40 T2 563 508 347 201 63 T1 541 488 335 182 52 Supplemental Figure 1

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Supplemental Figure 2

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