1. Alzheimer's disease 蕭尚益 丁唯洋 蔡欣容

3. Outline introductionDisease mechanismPreventConclusion

4. sympton  The loss of memory deterioration initial

5. Disease mechanism tangle plaque

6. Tangle

7. plaque  Beta-Amyloid

9. Can we treat Alzheimers 20 years early?

10. Too late?

11. 15% mild cognitive dementia Alzheimer’s Disease

12. Those who have mild cognitive dementia have already lost 55% to 70% key nerve and neuron in skin.

13. Result vs Cause

14. 15y s

16. People have amyloid positive but still normal already show change in their brain in these memory network.

17. Few drug work after their symptoms. We successfully deal with cancer, hreat attack..,because we treat them early and move toward prevention.

18. What we have today?  Symptomatic therapy → those drug help them a little bit.  Disease Modifying Therapy→ We don’t see decline at all.

20.  Some biologically active drug.  Monoclonal antibody  vaccine

21. Those therapy can’t help those who have had Alzheimer’s Disease in their brain and lose 70% of their neurons.

22. Secondary prevention AD trails.  Genetic at risk  Age at risk who are amyloid positive on biomarker  Those who have th AD process beginning in their brain.

23. conclusion