1. EYE MEDICAL FORMS Author: as. Yu.Yu. Plaskonis

2. Eye medical forms: solid, liquid, soft and gaseous. Eye medical forms: solid, liquid, soft and gaseous. Solid medical forms: pills, lamels, pencils, powders, tapes. Solid medical forms: pills, lamels, pencils, powders, tapes. Liquid medical forms: eye drops, washes, washings, solutions for injections and electrophoresis. Liquid medical forms: eye drops, washes, washings, solutions for injections and electrophoresis. Soft medical forms: ointments homogeneous and heterogeneous. Soft medical forms: ointments homogeneous and heterogeneous. Gaseous medical forms: aerosols. Gaseous medical forms: aerosols.

3. Eye drops (Guttae ophthalmіcae ) - are medical form, which shows by itself hydrogen's or oil solutions, and also suspensions which are intended for installation in a conjunctive bubble in a negligible quantity Eye drops (Guttae ophthalmіcae ) - are medical form, which shows by itself hydrogen's or oil solutions, and also suspensions which are intended for installation in a conjunctive bubble in a negligible quantity

4. Requirements for eye drops: sterility sterility isotonicity isotonicity stability stability exactness of concentration of operating matters; exactness of concentration of operating matters; transparency; transparency; absence of irritating and allergenic actions absence of irritating and allergenic actions to find out maximal biological activity to find out maximal biological activity in some cases do prolonged therapeutic effect. in some cases do prolonged therapeutic effect.

5. Aseptic terms - it the certain terms of work, and also complex of obligatory organizational measures which allow maximally to save medications, from a hit in them of microorganisms. Aseptic terms - it the certain terms of work, and also complex of obligatory organizational measures which allow maximally to save medications, from a hit in them of microorganisms.

6. Sterility - arrived at by preparation of eye drops in aseptic terms and their next sterilization.

7. Stability is arrived by the use of buffer solutions, stabilizations and by the correct selection of tableware, made from glass of brand NG (neutral glass)-1, NG-2, NG-3. Stability is arrived by the use of buffer solutions, stabilizations and by the correct selection of tableware, made from glass of brand NG (neutral glass)-1, NG-2, NG-3.

8. Absence of mechanical admixtures is provided by filtration

9. Isotones of eye drops conduct on principle of the same name of ions. Use: sodium chloride sodium chloride sodium sulfate sodium sulfate sodium nitrate sodium nitrate boric acid (only on a concordance with a doctor) boric acid (only on a concordance with a doctor) glucose (only on a concordance with a doctor) glucose (only on a concordance with a doctor)

10. For isotones use the isotonic equivalents of medicinal substances for sodium chloride. For isotones use the isotonic equivalents of medicinal substances for sodium chloride. Rp.: Sol. Pіlocarpіnі hydrochlorіdі 1% 10 ml іsotonіcae іsotonіcae D. S. For 2 drops in eyes D. S. For 2 drops in eyes 1. Е = 0,22. 2. 1,0 pilocarpine - 0,22 sodium chloride 0,1 - Х =0,022 0,1 - Х =0,022 3. 0,9 sodium chloride isotones 100 ml of water Х -10 ml Х -10 ml Х= 0,09 g Х= 0,09 g 4. Determine the amount of sodium of chloride, necessity for isotones of 1% solution of Pіlocarpіnі hydrochlorіdі 0,09 - 0,022 = 0,068  0,07 g 0,09 - 0,022 = 0,068  0,07 g

11. Technology depends on solubility of substances If a medicinal substance is well soluble in a solvent, dissolve in the half-note amount of solvent and filter in a small bottle for dispense through washed by water cleared fold filter and cotton wool, and then a filter is washed by other solvent. If a medicinal substance is well soluble in a solvent, dissolve in the half-note amount of solvent and filter in a small bottle for dispense through washed by water cleared fold filter and cotton wool, and then a filter is washed by other solvent. If a medicinal substance is difficult soluble, dissolve in totally of solvent and filter in the measured cylinder through a dry filter and cotton wool, and amount of water, that it is not enough, add through the same filter and cotton wool to the necessary volume of solution. If a medicinal substance is difficult soluble, dissolve in totally of solvent and filter in the measured cylinder through a dry filter and cotton wool, and amount of water, that it is not enough, add through the same filter and cotton wool to the necessary volume of solution.

12. Rp.: Sol. Zinci sulfatis 0,25 % 20 ml M. D. S. For 2 drops in an eye. WCP (r.s.) Zinci sulfatis 0,05 Aque purificatae 20 ml Natrii sulfatis 0,76

13. а) with the use of equivalents of zinc sulfate and sodium sulfate at sodium by a chloride: а) with the use of equivalents of zinc sulfate and sodium sulfate at sodium by a chloride: Amount of zinc sulfate : 0,25 - 100 ml Х - 20 mlХ = 0,05 Х - 20 mlХ = 0,05 Amount of sodium of chloride which answers the amount of zinc sulfate : 1,0 - 0,12 1,0 - 0,12 0,05 - ХХ = 0,006 0,05 - ХХ = 0,006 4. Amount of sodium chloride, necessity for isotones of eye drops: 0,18 - 0,006 = 0,174 Amount of sodium sulfate, necessity for isotones of eye drops : 0,23 sodium chloride - 1,0 sodium sulfate 0,174 sodium chloride – Х Х = 0,76

19. WCP (f.s.) Date№ of recipe Aquae purificatae 10 ml Zinci sulfatis 0,05 Natrii sulfatis 0,76 V = 20 ml Prepared 10 ml №2 Sterilis Prepared Checked Checked Registration to dispense. Labels: the "Eye drops", "Sterile", to "Save from children".

20. Rp.: Ung. Thiamini bromidi 0,5% 10,0 D. S. To mortgage for an eyelid. WCP (f.s.) Date № of recipe Date № of recipe Thiamini bromidi 0,05 (0,1) Aquae purificatae q.s. Thiamini bromidi 0,05 (0,1) Aquae purificatae q.s. Basis pro oculi sterile (8:2) 10,0 Basis pro oculi sterile (8:2) 10,0 m = 10,0 m = 10,0 Addita aseptice Addita aseptice Prepared Prepared Checked Checked