1. Biophysics 101 22 February 2007

2. ApoE assignment Merging input files – Mike Downloading multiple sequences – Christopher Nucleotide level mutations – Katie, Resmi, Xiaodi Mutations in introns or extrons - Zachary Protein level mutations – Katie, Resmi, Tiffany, Xiaodi Selective pressures on synonymous codon frequency - Kay

3. Final project ideas Application –Alzheimers desease –Identify causal relationships gene  desease – genome level –Bioenergy – cellulosic fuel –Agroplanning and modelling –Genotype – Expressiontype –Genotype  RISK – OMIM –Desease outbreak – BIOMAP –Personal diagnosis - webMD Input –1 gene (ApoE) –Particular desease genomes –Random genomes or exonic sequences Characterization –Identify variation (Coding and Non Coding) –Codon usage Analysis –Evolutionary processes (Codon bias selective pressure) –Well known desease associations Action –Medical / dietary action –Directing research efforts

4. OMIM Online Mendelian Inheritance in Man http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=OMIM http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=OMIM OMIN Stats http://www.ncbi.nlm.nih.gov/Omim/mimst ats.html http://www.ncbi.nlm.nih.gov/Omim/mimst ats.html