1. DoD Global Influenza Surveillance 2004-2005 Linda C. Canas Epidemiology Services Branch Brooks City-Base, TX February 16,2005 Vaccines and Related Biological Products Advisory Committee Meeting

2. History PREVENT OUTBREAKS ….. healthy troops 1976 U.S. Air Force begins sureillance –Isolate and Identify circulating influenza virus –Detect emerging variants –Evaluate effectiveness of vaccine

3. Population Based Surveillance Naval Health Research Center San Diego, California Etiology Based Surveillance Brooks City-Base San Antonio, Texas Influenza Surveillance

4. DoD Global Influenza Surveillance.................IN ACTION.................IN ACTION DoD GEIS Epi Services Branch Laboratory Routine & Annual Reports; End of Season business meeting Collect and ship Samples Sentinel Sites Program Guidance & routine reports Conventional/ Molecular Laboratory Methods Flu Isolated Selected Samples CDC Vaccine Decisions Molecular Sequences Supplies FedEx Support Funding & Guidance

5. DoD Influenza Surveillance Sentinel Sites 2004-2005

6. Vaccination Stats 80% of AD AF personnel have been vaccinated as of 14 Feb 05 Recruits have received FluMist No virus tested has been consistent with the seed virus for FluMist

9. K145N

11. Results from New York and New Jersey

12. Results from Virginia, Georgia, Alabama and Mississippi

13. Results from Texas, Louisiana and Oklahoma

14. Results from Illinois

15. Results from Colorado

16. Results from UK, Germany, Italy, and Turkey

18. Results from Alaska, Hawaii, Guam, Korea, Japan

19. Results from Peru

20. A Six-Seasonal Year Review 1998-1999 through 2003-2004 Seasonal Year Specimen Result 1998-19991999-20002000-20012001-20022002-20032003-20042004-2005* Negative73%59%66%61%58% 63% Adenovirus3%33%16%18%20%11%5% Enterovirus0% 1% Herpes Simplex Virus 2%1% 2%1% 2% Influenza A15%6% 14%8%25%26% Influenza B5%1%7%3%8%2%3% Parainfluenza2%1% 2% 1% Respiratory Syncytial Virus 0% 1% 0% *2004-2005 data includes specimens collected from 01 October 2004 through 4 February 2005.