1. Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA بسم الله الرحمن الرحيم بسم الله الرحمن الرحيم

2. Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdullaziz University. Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdullaziz University. NEOPLASIANEOPLASIA

3. Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA NEOPLASIA What Why Where When How

4. Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA An abnormal mass the growth of which exceeds and is uncoordinated with that of the normal tissue and persists in the same excessive manner after the cessation of stimuli which evoked the change. Definition :

5. Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA DIFINITIONS  TUMOR VS NEOPLASM  ONCOLOGY= ONCOS + LOGOS  BENIGN = RELATIVELY INNOCENT  MALIGNANT = CANCER ( CRAB )

6. Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Nomenclature

7. Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Benign tumors: oma + cell type Papilloma : benign surface neoplasm

8. Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Benign tumors A Polyp : mass projecting above a mucosal surface

9. Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Benign tumors An Adenoma: benign epithelial neoplasm producing or arising from glands

10. Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Benign tumors connective tissue Leiomyoma : A benign neoplasm of smooth muscle

11. Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Leiomyoma DR OSAMA I NASSIF FRCPC NEOPLASIA LEIOMYOMA HPF

12. Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Nomenclature

13. Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Benign tumors Fibroadenoma : more than one cell type, from one germ layer

14. Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Benign tumors Mixed tumor of salivary glands (pleomorphic adenoma) Derived from one germ layer

15. Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Nomenclature

16. Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Benign neoplasms Mature teratoma :more than one neoplastic cell type derived from more than one germ layer. Mature teratoma :more than one neoplastic cell type derived from more than one germ layer.

17. Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Malignant tumors

18. Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Benign Vs malignant

19. Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Malignant neoplasms differentiation and anaplasia Adenocarcinoma

20. Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Malignant neoplasms Squamous cell carcinoma: Well-differentiated. Differentiation and anaplasia

21. Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Benign vs Malignant

22. Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Anaplasia Pleomorphism Hyperchromasia High N/C ratio Polynuclearity High mitotic rate Bizarre shapes/sizes Atypical mitoses

23. Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA HAVE A NICE DAY