1. Jin MENG Shen FU 57090 (DPD 08) Biology 2 - Head/Neck and CNS Tumors
Validation of a radiosensitivity gene signature in radiotherapy-treated patients from The Cancer Genome Altas (TCGA)
Jin MENG Shen FU
57090
(DPD 08) Biology 2 - Head/Neck and CNS Tumors

2. Background Identification of 31 radiosensitivity genes
in NCI-60 cell line
BMC Genomics 13, 348 (2012)

3. Workflow
Validation of radiosensitivity gene signature in RT-treated patients
mRNA profiling expression of 16 different cancer types from TCGA
Exclude cancer types without RT or survival information
GBM (n=463)
HNSCC(n=92)
LGG(n=151)
Clinical characteristics
Kaplan-Meier curves
Multivariate Cox regression analysis
Comparison between RS and RR patients

4. Results a b
P<0.001
P=0.004 c
Tumor classification by radiosensitivity gene signature shows distinct prognostic outcomes of (a)GBM patients(n=463) (b)HNSCC patients(n=92) (c)LGG patients(n=151)
P=0.128

5. Take home messages
Our study demonstrates the potential prognostic values of radiosensitivity gene signature identified by Kim et al.
The gene signature is a predictive biomarker for radiotherapy treatment benefit for GBM and HNSCC patients.
Future prospective studies will be needed to fully refine the integrated prognostic algorithm in clinical radiation oncology.

6. Thanks