1. General Pathology Concepts, Case 2 70 year-old male complained of chest pain with inspiration. He developed hemoptysis and dyspnea. He has metastatic colon cancer and a swollen left leg.

2. Identify the organ Describe the gross morphologic changes Diagnosis?

3. Lungs removed en-bloc during autopsy The arrow points to an embolus extending through the branches of a pulmonary artery.

4. Identify the organ Describe the gross morphologic changes Diagnosis?

5. Pulmonary Infarct (arrow) Pulmonary infarcts are typically pyramidal with base at the pleura. Only about 10% of pulmonary emboli actually cause infarction. Why?

6. Pulmonary Infarct (arrow) Pulmonary infarcts are typically pyramidal with base at the pleura Only about 10% of pulmonary emboli actually cause infarction. Why? In patients with adequate cardiovascular function, the bronchial arterial supply can often sustain the lung parenchyma despite obstruction of the pulmonary arterial system..

8. alveoli Hemorrhage into infarcted lung Infarcted alveolar septa (note no nuclei)

10. Pulmonary arterial thrombus