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Definitions Mutation – any change in the genetic sequence.

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Presentation on theme: "Definitions Mutation – any change in the genetic sequence."— Presentation transcript:

1 Definitions Mutation – any change in the genetic sequence.
Gene alteration – when a change in the genetic code changes the amino acid sequence Silent mutation- when a change in the genetic code doesn’t change the amino acid sequence

2 Kinds of mutations Point mutation – change in just one nucleotide AAA mutates to AAG Insertion mutation – change in sequence by adding one or more bases. Deletion mutation – change in sequence by taking out one or more bases. Frame shift mutation – the result of an insertion or deletion that moves the codons down and changes all the amino acids

3 Frame shift mutation example
AAG TAG CAT ACT AAT AGC ATA CT_

4 Mutation Worksheet #1 Original DNA: Amino Acid sequence
AGA GCA CTT AAA AGG Amino Acid sequence SER-ARG-GLU-PHE-SER Mutated sequence: AGA GCG CTT AAA AGG Amino Acid sequence: Type of mutation: Point mutation Gene alteration: None

5 Mutation Worksheet #2 Original DNA: Amino Acid sequence
AGA GCA CTT AAA AGG Amino Acid sequence SER-ARG-GLU-PHE-SER Mutated sequence: AGA GCA CTT AAT AGG Amino Acid sequence: SER-ARG-GLU-LEU-SER Type of mutation: Point mutation Gene alteration: yes, but only one a.a.

6 Mutation Worksheet #3 Original DNA: Amino Acid sequence
AGA GCA CTT AAA AGG Amino Acid sequence SER-ARG-GLU-PHE-SER Mutated sequence: AGA CAC TTA AAA GG Amino Acid sequence: SER-VAL-ASP-PHE-___ Type of mutation: deletion; frame shift Gene alteration: yes, frame-shift

7 Mutation Worksheet #4 Original DNA: Amino Acid sequence
AGA GCA CTT AAA AGG Amino Acid sequence SER-ARG-GLU-PHE-SER Mutated sequence: AGA GCA ATC CCG TTC GGG CTT AAA AGG Amino Acid sequence: SER-ARG-STOP Type of mutation: insertion Gene alteration: yes, significant

8 Mutation Worksheet #5 Original DNA: Amino Acid sequence
AGA GCA CTT AAA AGG Amino Acid sequence SER-ARG-GLU-PHE-SER Mutated sequence: AGA GCA AAA AGG Amino Acid sequence: SER-ARG-PHE-SER Type of mutation: deletion Gene alteration: yes, missing an a.a.

9 6. When a point mutation results in the same amino acid sequence, is it still considered a mutation?
Yes because a mutation is a change in the genetic code and it may or may not result in a change in the amino acid sequence. A mutation that doesn’t result in a change in the amino acid sequence is called a silent mutation

10 Mutation Worksheet # Original DNA: Amino Acid sequence
AGA GCA CTT AAA AGG Amino Acid sequence SER-ARG-GLU-PHE-SER Mutated sequence: Amino Acid sequence: Type of mutation: Gene alteration:

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ATG GAG GAA GAA GAT GAA GAG ATC TTA TCG TCT TCC GAT TGC GAC GAT TCC AGC GAT AGT TAC AAG GAT GAT TCT CAA GAT TCT GAA GGA GAA AAC GAT AAC CCT GAG TGC GAA.

ATG GAG GAA GAA GAT GAA GAG ATC TTA TCG TCT TCC GAT TGC GAC GAT TCC AGC GAT AGT TAC AAG GAT GAT TCT CAA GAT TCT GAA GGA GAA AAC GAT AAC CCT GAG TGC GAA.
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