1. Vessels, Organs and Tissues
Lymphatic System
Vessels, Organs and Tissues

2. Lymphatic System Vessels: Connect to CV Organs: house immune cells
Capillaries
Collecting vessels
Trunks
Transport fluid => lymph
Organs: house immune cells LN
Spleen
Thymus
Tissues
Tonsils
GALT
MALT

3. Fluid Compartments Capillary Dynamics Fluid Compartments
Hydrostatic/Hydraulic
Osmotic
Fluid Compartments
ICF
ECF
ISCF
Plasma
Lymph

4. Lymphatic Capillary

5. Lymph Flow

6. Lymphatic Valve

7. Lymphatic Vessels and Ducts

8. Thoracic Duct

9. Lymph Return

10. Problem Lymph Return : Lymphedema

11. Lymphatic Vessel Circuits

12. Lymph Node: Location

13. L.N. : Specimen

14. Lymph Node: Gross Anatomy
1. Afferent Lymphatics
2. Cortex
3. Germinal Center
4. Capsule
5. Medullary cord
6. Valve
7. Efferent Lymphatics

15. LN Structure: CT and vessels
Capsule
Subcapsular sinus
Trabecula
Reticular CT stroma
Vessels
Types
Afferent
Efferent
Valves

16. Lymph Node

17. Lymph Node: Histology
B cells
T cells MO

18. Lymph Node: Capsule Region

19. Lymph Node: Cortex
Lymphatic Nodule
Germinal Center

20. Lymph Node: Medulla

21. Lymph Node: Medullary Cords
Sinusoids
Macrophages

22. L.N. Medullary Cells
P = Plasma cells (daughter cells of Activated B cells
M = Macrophages (mature monocytes in tissues)

23. LN Histology Summary

24. Diagnostics for Lymphatics and LN
Lymphangiogram

25. Lymphatic Problem: Lymphoma

26. Lymphatic Nodule: Basic structure for All Lymphatic tissue

27. Spleen: Location

28. Spleen: Gross Anatomy

29. Spleen: Histology
Splenic
Sinusoid

30. Spleen Problems
Rupture
Cancer
Infection
Hydatid cyst

31. Thymus: Location

32. Thymus: Gross

33. Thymus Embryological Development
1. Mandibular arch
2. Hyoid arch
3. Cervical sinus entry
4. 3rd pharyngeal pouch
5. 4th pharyngeal pouch
6. Foramen cecum
7. Thyroid
8. Cervical sinus
9. Thymus (3rd pouch)
10. Thymus (4th pouch)

34. Thymic Cell Development
1. Thymic capsule
2. Thymic nurse cells
3. CT septa and BV
4. Subcapsular epithelium (for the blood thymus barrier)
5. Cortical Epithelial cells
6. Medullary epithelial cells
7. Dendritic cells
8. Hassall’s Corpuscle
9. Macrophages
10. Cortex
11. Medulla

35. Thymic Organization

36. Thymic Capsule, Septa and Lobules

37. Thymus: Cortex

38. Thymic Medulla

39. Thymic Age Degeneration

40. Thymic Problem
Thymic Aplasia

41. Tonsil: Location
Pharyngeal [Adenoids]
Palantine
Lingual
Tubal

42. Palatine Tonsil

43. Tonsil: Epithelial Histology

44. Tonsil Lymphatic Nodules

45. Tonsilar Crypt

46. Tonsil Problem: Tonsillitis

47. Gut Associated Lymphatic Tissue (GALT) Location

48. GALT

49. Peyer’s Patches

50. Ileum Problems
Inflammation
Necrosis

51. Appendix: Gross

52. Appendix

53. Appendix Problems
Appendicitis
Appendix rupture and necrosis

54. MALT
epiglottis
bronchus

55. Summary Overview

56. Questions?