1. areta@aretaint.com www.aretaint.com

2. ARETA INTERNATIONAL S.r.l. The Reliable Partner for the Development of Biodrugs in the field of Advanced Therapies

3. From the development of cell line to the final doses for patients THE QUALITY AS BUSINESS MODEL All company is ISO 9001:2000 certified since its founding (1999) High Containment Production Plant for cell culture GMP Authorized by the Italian Ministry of Health (in compliance with European Law) Quality Agreement where necesssary THE COMPETENCES High skill in the development of biodrugs (cells, antibodies, rec proteins) Tumors,,CNS and Metabolic Diseases as Targets THE RESEARCH Collaboration with Italian and Int. Research Inst. Partecipation to National and Int. Res. Projects 20% of the staff in dedicated to Research THE PORTFOLIO OF PRODUCTION Process developmment Production of lots for pre-clinical and clinical studies Filling in asepsis of bags, vials…and media fill QC and Safety tests set up and validation Batch release by in house Qualified Person ARETA OPERATES AS CUSTOMIZED CMO ON A CONTRACT BASE IN PARTNERSHIP FOR CODEVELOPMENT WHY CHOOSE US HIGH COMPETITIVENESS FLEXIBILITY TIMING TAILORED BATCHES (also SMALL) PRICING INNOVATIVE APPROACH TO MANUFACTURING

4. A New International Strategic Alliance Biotechnology, Development of Advanced Therapy Drugs New formulations, pharmaceutical chemical and bio-analyses, pharmacokynetics Drug development/registrations; international Business Development