1. Making blood activity Inquiry resource
Blood components
Making blood activity
Inquiry resource

2. Disturbing?

3. Components of Blood

4. Blood average 4-5L in a human body Blood is a connective tissue
When centrifuged, blood separates into two major components:
Plasma(55%)
Formed elements (45%)

5. Blood’s components RBC, WBC, and platelets 1. Plasma
Fluid part of the blood
92% water
1% ions (Ca 2+, Na+, K+, Cl-, etc.)
7 % proteins (albumins, globulins, fibrinogen)
Serum = plasma –( fibrinogen +clotting factors)
2. Cellular components
(also Formed elements):
RBC, WBC, and platelets

6. To fill in the info on slide 13-17; use the provided summary table on Cellular component of blood. Your table should look like the page on the right here

8. Red Blood Cell (erythrocytes_)
2. Cellular Components (previously called Formed elements)
Description
Function
Red Blood Cell (erythrocytes_)
99% of Cellular Components
tiny biconcave disks (135 RBC = 1mm). Biconcave shape increases surface area
Can fold to pass through narrow blood vessels
Made from stem cells in bone marrow
Lack mitochondria and nuclei
Stored in spleen
Constantly being destroyed and replaced (~120 days)
Carry O2 & CO2
Have iron-containing protein called hemoglobin (~ 280 mill/1 RBC) specializing at transporting O2
1 hemoglobin can bind 4 O2
Anemia are conditions of haemoglobin shortage
Erythrocytes that have a normal size or volume (normal MCV) are called normocytic,
When the MCV is high, they are called macrocytic.
When the MCV is low, they are termed microcytic. Erythrocytes containing the normal amount of hemoglobin (normal MCHC) are callednormochromic.
When the MCHC is abnormally low they are calledhypochromic, and when the MCHC is abnormally high,hyperchromic.

9. When bio meets chem:
A hemoglobin can hold 4 O2. There are about 280 million hemoglobin in a red blood cell. How many moles of O2 does a RBC contain?

10. Pus White Blood Cell (Leucocytes) Produced in the bone marrow
2. Cellular Components of Blood (Cont)
White Blood Cell (Leucocytes)
Produced in the bone marrow
Do have nuclei
5-9 mill./1cm3 of blood
Male 10% more WBC than female
Many different types
1. Neutrophils
2. Basophils
3. Eosinophils
4. Lymphocytes
5. Monocytes
Defend against diseases and infections
Function in allergic reactions
Produce antibodies stimulated by binding of foreign particles
Phagocytize (i.e. engulf) to destroy invaders
Leukemia – cancer of the wbc (wbc can’t stop dividing)
Pus

11. Histology of WBC
WBC

12. Platelets (thrombocytes) Fragments of cells 1-3um; no nuclei
2. Cellular Components of Blood (Cont)
Platelets (thrombocytes)
Fragments of cells
1-3um; no nuclei
Break down after 7-10 days
Responsible for blood clotting
Prevent excessive blood loss
Hemophilia – Sex-linked condition resulting in excessive bleeding
This medication is used to prevent and treat blood clots. It may be used to prevent and treat blood clots in the lungs/legs (including in patients with atrial fibrillation). It may be used to treat certain blood clotting disorders. It may also be used to prevent blood clots after surgery, during dialysis, during blood transfusions, when collecting blood samples, or when a person is unable to move for a long time. Heparin helps to keep blood flowing smoothly by making a certain natural substance in your body (anti-clotting protein) work better. It is known as an anticoagulant.
How blood clots?
Let’s go to the ER:

13. Consolidation- HW Blood component summary table