1. Health & Social Care Research Strategy 2015- 2020 Delivering Innovation through Research Scottish Government Health and Social Care Research Strategy http://www.gov.scot/Publications/2015/10/5164

2. Why should Scotland do clinical research The ambition of this strategy is to increase the level of high- quality health research conducted in Scotland, for the health and financial benefits of our population, so that we are recognised globally as a leader in health science. Research central to ethos of evidence-based person-centred healthcare system Access to clinical trials for Scottish patients Inward investment

3. UK – wide comparison Office for National Statistics Scotland, 2013: – ~8.3% of UK – ~10% compared to England

4. Academic Strengths 11.8% of UK health research expenditure in Scotland (UKCRC, 2015) Scotland has 8.3% of UK population

5. Territorial Health Boards NWTCB 3

7. CSO Annual Budget – approx. £68 m NHS Research Scotland Support Budget - £44 m meets the costs to the NHS of hosting and participating in clinical research NHS Support Costs Excess Treatment Costs Researcher Support Budget Around 190 wte NHS posts (research nurses, data managers, radiologists etc) NRS Fellowship Scheme Topic-specific research networks and specialty groups

8. Networks and Specialty Groups Supporting recruitment and delivery to studies is the primary goal All eligible or commercial studies are supported Every eligible, commercial, (or NIHR adopted) study is the responsibility of at least one Network or SG Together, this ensures national oversight of all eligible studies within each specialty

9. NRS Performance Manager Surgery I&E Anaesthesia NRS Neurodegener ative Disease Network NRS Diabetes Network NRS Primary Care Network NRS Paediatrics Network NRS Stroke Network NRS Mental Health Network NRS Cancer Network NRS CV Manager NRS RH & C Manager NRS MSK Manager Dermatology Lead Dermatology Lead Respiratory Lead Respiratory Lead Hepatology Lead Hepatology Lead Cardiovascular Champion Cardiovascular Champion Cancer Champion Paediatrics Champion Paediatrics Champion Stroke Champion Stroke Champion Primary Care Champion Primary Care Champion Mental Health Champion Mental Health Champion Diabetes Champion Diabetes Champion MSK Champion MSK Champion Infec’s D’ses & Microbi’y Lead Infec’s D’ses & Microbi’y Lead Renal Lead Renal Lead Gastroen’y Lead Gastroen’y Lead Metabolic & Endocrine Lead Metabolic & Endocrine Lead Critical Care Lead Critical Care Lead Age & Aging Lead Age & Aging Lead Oral & Dental Lead Oral & Dental Lead N-M haematology Lead N-M haematology Lead Genetics Lead Genetics Lead Ophthalmology Lead Ophthalmology Lead ENT Lead ENT Lead Reprod. H’th & Childbirth Champion Dementia & ND Champion NRS West Node NHS Ayrshire & Arran, NHS Dumfries & Galloway, NHS Greater Glasgow & Clyde, NHS Lanarkshire, NHS NWTCB NRS West Node NHS Ayrshire & Arran, NHS Dumfries & Galloway, NHS Greater Glasgow & Clyde, NHS Lanarkshire, NHS NWTCB NRS North Node NHS Grampian, NHS Highland, NHS Orkney, NHS Shetland, NHS Western Isles, NRS North Node NHS Grampian, NHS Highland, NHS Orkney, NHS Shetland, NHS Western Isles, NRS East Node NHS Fife, NHS Forth Valley, NHS Tayside NRS East Node NHS Fife, NHS Forth Valley, NHS Tayside NRS South East Node NHS Borders, NHS Lothian NRS South East Node NHS Borders, NHS Lothian NRS Champions NRS Research leads NRS Nodal Delivery Infrastructure Revised Structure

10. What is SHARE? A register of people aged 16 or over and living in Scotland who have said they are interested in helping with medical research. They give permission to for the NHS to check their Datasets to see if they may be suitable for research projects. 90,000 signed up as of last Wednesday Extend to NHS staff using NHS patient records solely to advise GP’s and hospital consultants of studies that may be of interest to their patients? Proposed amendments to EU Data Protection Regulations?

11. Annual Budget – approx. £68 m UK Research Contribution - £7.7 m Allows Scottish-based researchers to apply for NIHR research grants

13. NETSCC programme eligibility Researchers in Scotland can be principle applicants to NETSCC programmes (*can be co-applicants to all) Programme Commissioned stream Researcher-led stream Themed calls EMEYYY HTAYYY PHRYYY HS&DRN*YY

20. CSO Strategic Priorities Maximise Scottish success in NETSCC schemes Positioning of ETM and HSP committees accordingly Address Scottish Government policy driven research needs Target funding through collaborations and/or specific initiatives Operational Priorities More efficient processes – allow CSO to do more with same resource Research Funding

21. Outline of CSO grant schemes Catalytic research grants Response mode research grants Themed research calls directed to – special initiatives around emerging opportunities – Scottish Government policy priorities Clinical research fellowships Charity co-funding initiatives

22. Catalytic research grants Launch 1 st February 2016 Objective Applications are strengthened by supporting evidence of feasibility or proof of principle. To support successful applications to other funders, small grants for work to provide supporting evidence / groundwork for applications for health research to other funders. Characteristics Small (≤ £35k, no FEC) and short (≤ 6 months duration) project Quick decision based on short application Broad scope (e.g. survey, focus group, consensus-forming meeting, analysis, testing samples, acceptability/feasibility study, audit) but adhering to usual research governance requirements Applicant must demonstrate potential utility to support application to another funder for health research (across CSO committee remit) No deadline – applications submitted at anytime (but may close scheme during year depending on budget) - Usual CSO eligibility requirements Excludes Stand-alone work with no firm plan for follow on application. Work to support applications to CSO

23. Catalytic research grants Process Short application (<4 pages): applicant details, context and why work is needed, utility to support grant to other funder, details of funder and scheme, work plan, resource justification Submitted through research office Reviewed by CSO +/- external peer-review with decision within 1 month Output Short report describing what was done, why and the next steps, financial reconciliation. 1 year CSO follow up after completion to establish outcome.

24. CSO research funding committees 2 committees – each 2x per year – up to 4 projects funded per meeting Funding limit raised to £300,000 per application (80% full economic cost) Remit Health Services / Public Health Translational Medicine Eligibility Scottish-based PI / CI Research must be of relevance to health / well-being of Scottish population Response Mode Grants

25. Translational Clinical Studies Research Committee The Committee considers applications for research aimed at improving treatments and / or diagnostic approaches for conditions of clinical importance to the population of Scotland. Applications must demonstrate the clinical relevance of the research and its potential for translation into clinical practice. Applications that seek to address questions of clinical importance in small patient groups (e.g. rare diseases) are welcomed.

26. Health Improvement, Protection and Services Research Committee The Committee considers applications for research aimed at improving or protecting population health or improving the quality, safety and/or effectiveness of healthcare in Scotland. Applications must demonstrate the relevance and importance of the research and its potential for significant impact on health in Scotland. A clear pathway for translation of the results into policy and/or practice must be presented.

27. Process changes Initial 4 page synopsis – scored against set criteria by committee members Reject – feedback provided Proceed to full application – around 12-15 per round Revised full application form More clearly defined translational focus Why CSO and not NETSCC / Research Council / Medical Research Charity Emphasis on applicants to identify external reviewers Response Mode Grants

31. Common pitfalls Proposals that are well written / scientifically sound without addressing an issue of clinical importance unlikely to be funded Put together strong team of CoI’s – multidisciplinary / multicentre Don’t try and “squeeze” a larger research proposal into the £300K limit - CSO contributes ~ £8 million per year to allow Scottish access to NIHR programmes Engage with NHS R&D / University Research Office early

32. Collaborative funding with medical research charities Alzheimer’s Research UK – research project Prostate Cancer UK – research project Action Duchenne / M.D.UK – clinical fellowship MND Assoc. / MND Scotland – clinical fellowship Scottish Huntington’s Assoc. (with RS Macdonald Trust) – academic fellowship Stroke Association – Research Project and Senior Clinical Lectureship Breast Cancer Now – research project Pancreatic Cancer UK – research project- 2 call now live Marie-Curie – research project – up to £450K Action Medical Research – 2 x research projects – up to £200K each Wellbeing of Women – research project – up to £200K British Lung Foundation – research project – up to £300K Arthritis Research UK – research project – pre-call Progressive Supranuclear Palsy Association – clinical fellowship

33. Research Fellowships Clinical Academic Fellowships Applications through host institution Typically completed NTN 3 year duration – PhD CSO covers salary, PhD fees, £10K per year consumables 2015 round closed – rolling programme of charity co-funded fellowships Scottish Senior Clinical Fellowship Scheme Five years of “protected” time in which to develop an internationally competitive research programme Five years of support for a research assistant (@ £35k pa total salary costs), research consumables (@ £23k pa), and £60k to contribute to the costs of one PhD student over the 5 year period. Closing date for next round Feb/Mar 2016

34. Contact Details alan.mcnair@gov.scot 0131 2448494 tom.barlow@gov.scot 0131 2448350 http://www.cso.scot.nhs.uk/