1. Cardiovascular = Circulatory System Blood

2. Blood General functions Amount of blood – 5-6 liters in males, 4-5 liters in females – 8% of body weight

4. FORMED ELEMENTS Cells 45% blood

6. Erythrocytes = RBCs 4-5 million/mm3 Hemoglobin – Iron – Function – Color

9. RBCs Hemopoiesis Erythropoiesis (2 million/second) Life span about 120 days Destroyed and recycled by liver & spleen Erythropoeitin

12. RBCs Stay in blood vessels ABO system Antigen Antibody A,B,AB,O blood types

15. RBCs Rh factor Erythroblastosis fetalis

17. Leukocytes = WBCs 5000-9000/mm3 Granulocytes – Neutrophils (pale granules, segmented nucleus, most numerous, phagocytosis) – Eosinophils (red granules, segmented nucleus, phagocytosis, attacks parasites) – Basophils (purple granules, semented nucleus, releases histamine & heparin

18. Agranulocytes – Lymphocytes (T & B, immunity, round nucleus) – Monocytes (bean-shaped nucleus, foamy cytoplasm, exit bloodstream & enlarge and become MACROPHAGES)

19. Life span Formation

23. Function of WBCs Phagocytosis – Lytic enzymes – Macrophages Antibodies – Plasma Cells – Vaccination T cells

24. Thrombocytes = Platelets 100,000-300,000/mm3 Stays in blood vessels Life span Production in bone marrow

27. Hemostasis Vascular constriction Platelet plug formation – ADP

29. Hemostasis - Coagulation Conversion to an insoluble fibrin clot Clotting factors Fibrinogen is converted to Fibrin By Thrombin – precursor is prothrombin Liver makes clotting factors Vitamin K

31. Coagulation Extrinsic mechanism – 15-20 seconds – Initiates with damaged tissue releasing thromboplastin Intrinsic mechanism – 1-2 minutes – Hemophilia

33. Clot Retraction 30-60 minutes later Serum

34. Clot Control Heparin from mast cells Basophils Endothelium is smooth

35. Fibrinolysis Clot dissolution Plasmin

37. Intravascular Clotting Thrombus Embolus (Embolism)

38. Plasma 55% of blood Water – Over 90% Proteins – Albumin – Globulin – Fibrinogin

40. Interstitial Fluid Similar to plasma Bathes tissues