1. Cancer.orgPredict Results of a multicentric in silico clinical trial (ROCOCO): comparing radiotherapy with photons and protons for non-small cell lung cancer Erik Roelofs MSc Medical Physicist MAASTRO CLINIC Maastricht, Juli 2011

2. Flowchart to determine eligibility of a patient to receive proton therapy. *Using peer-reviewed, published and externally validated models. Roelofs et al., J. Thorac Oncol, 2011

3. Comparison of dose distributions of 3DCRT, IMRT and PSPT treatment plans (columns) for three cases (rows). The target is shown (thick red line) with isodose lines of 1, 10, 25, 50 and 67 Gy (thin red line). #2 #15 3DCRTIMRTPSPT #6 Roelofs et al., J. Thorac Oncol, 2011

4. DVHs for patient #2 where the prescribed dose of 70 Gy resulted in exceeding the critical MLD level. Shown are DVHs for 3DCRT (solid), IMRT (dashed) and PSPT (dotted) plans. *MLD refers to the DVH of both left and right lung volumes minus the GTV. DVHs for patient #2 – Prescribed dose (70Gy) Roelofs et al., J. Thorac Oncol, 2011

5. DVHs for patient #2 where the dose was lowered to the maximum tolerable dose, showing larger under-dosage for 3DCRT (solid) than for IMRT (dashed) or PSPT (dotted). *MLD refers to the DVH of both left and right lung volumes minus the GTV. Roelofs et al., J. Thorac Oncol, 2011 DVHs for patient #2 – Maximum Tolerable Dose