1. CYSTIC FIBROSIS AND CELL COMMUNICATION

2. CFTR Cystic Fibrosis Transmembrane Conductance Regulator ( Or CFTR)  Is a transport protein for Chloride across cell membranes.  Helps in the production of mucus, urine, and other waste products  Allows free flow of water and Cl - ions throughout the cell.

3. CYSTIC FIBROSIS AND DISRUPTION OF CFTR Cause:  Cystic Fibrosis is caused by a mutation of CTFR, most commonly a deletion of three nucleotides.  CF is an autosomal recessive disease  Salt and water are no longer able to move in and out of the cell freely, as they were prior to this mutation.

4. SYMPTOMS  Symptoms of CF include:  Sinus Problems/Frequent Infections  Frequent Lung Infections  Abnormal Pancreas Function  Can Lead To Diabetes  Difficulty Digesting Food  Poor Growth and Nutrition  Causes Infertility

5. TREATMENTS  Pulmonary Rehab  Usually Steroids are administered to stimulate cell activity  Synthetic Protein Channels  Complete Lung Replacement  As cells continue to deteriorate, a total lung transplant becomes required  Insulin injections and pumps are frequently used to treat the symptom of diabetes.

6. SYMPTOMS CONT.  Deterioration of cells usually lead to shorter lifespan in people with CF  People with CF, on average, develop diabetes at a much earlier age than people without.

7. GENETICS  CF is a recessive gene disorder  Most commonly caused by a loss of the amino acid phenylalanine  Most people have to copies of the CFTR protein, two mutated copies are needed to cause Cystic Fibrosis.

8. CONCLUSION  Add your conclusion here

9. QUESTIONS & DISCUSSION