1. o Single gene Mendelian disorder o Gene codes for the Cystic Fibrosis Transmembrane Conductance Regulator protein (CFTR) Daniel R. Taub and Joshua Page. Cystic Fibrosis: Exploration of evolutionary explanations for the high frequency of a common genetic disorder.

2. o Transmembrane Cl - channel protein o Gene located on human chromosome seven o More than 1400 alleles with diminished function o Most common CF disorder allele is  Daniel R. Taub and Joshua Page. Cystic Fibrosis: Exploration of evolutionary explanations for the high frequency of a common genetic disorder.

3. A: A dominant allele B: A recessive allele C: Neither dominant nor recessive Daniel R. Taub and Joshua Page. Cystic Fibrosis: Exploration of evolutionary explanations for the high frequency of a common genetic disorder.

4. A: They would have cystic fibrosis B: They would not have cystic fibrosis Daniel R. Taub and Joshua Page. Cystic Fibrosis: Exploration of evolutionary explanations for the high frequency of a common genetic disorder.

5. o Impaired lung clearance of mucous o Recurrent lung infection and inflammation o Pancreatic damage o Impaired digestion Daniel R. Taub and Joshua Page. Cystic Fibrosis: Exploration of evolutionary explanations for the high frequency of a common genetic disorder.

6. o Historically, most CF individuals would die in early childhood o Improved medical care has raised median lifespan into the fifth decade. Daniel R. Taub and Joshua Page. Cystic Fibrosis: Exploration of evolutionary explanations for the high frequency of a common genetic disorder.