1. Protein Function What happens when a protein’s environment is changed?changed

2. Protein Structure based on the sequence of amino acids. If the sequence changes, the protein changes

3. Protein Folding The structure (how its folded) of the protein affects the function. Changing one amino acid can change the shape which alters the function resulting in genetic disorders

4. Structure Meets Function: Making a Protein TASK: Create a protein (Pencil Transferase) with a pipe cleaner that can move a pencil from one desk to another.

5. Structure Reflects Function The SHAPE of the pipe cleaner allows it to perform its FUNCTION Just like pipe cleaners, proteins are folded into specific shapes to perform their functions! Handle Domain Pencil-Binding Domain

6. Videoclips: VideoclipVideoclip – One Wrong Letter – Tay Sachs VideoclipVideoclip – Finding Cures is Hard– Cystic Fibrosis

7. Cn3D – Viewing 3-D Proteins Hemoglobin BRCA1 – no mutation (methionine - M) BRCA1 BRCA1 – mutation (Loc 130 - arginine - R) Videoclip: BRCA1 and Breast Cancer Videoclip – Complexity in Proteins Videoclip

8. The Genetic Code - 20 amino acids Uses 3 letter “words” (codons) that translate to amino acids 3 bases = codon AUG = start UAG,UAA,UGA = stop