1. Exercise and adult women’s health Amos Pines

2. Exercise improves cardiovascular risk profile Body mass index Total, abdominal (subcutaneous and visceral) fat Waist circumference Glucose metabolism/insulin resistance Blood pressure Lipids Endothelial function/intima-media thickness IMPROVED

3. Exercise and cardiovascular morbidity The WHI observational trial data: Up to 45% decreased risk for cardiovascular events, correlated with the degree of energy expenditure (MET) Manson JE, et al. N Engl J Med 2002;347:716 p < 0.001 White women (n = 61,574) LowestHighest Quintile of total MET score 1.00 0.85 0.70 0.66 0.55 1.2 1.0 0.8 0.6 0.4 0.2 0.0 1234512345

4. Exercise and breast cancer risk High calorie intake and high BMI are known risk factors for breast cancer in postmenopausal women 38,660 women (age 55–74); 10-year follow-up > 4 hours/week of vigorous physical activity resulted in 22% reduced risk for breast cancer as compared to non-actives Women with the most unfavorable energy balance (high energy intake, high BMI, physically inactive) demonstrated a two-fold risk versus those with most favorable data Chang SC, et al. Cancer Epidemiol Biomarkers Prev 2006;15:334

5. Counseling on exercise Mean age 57 years; 67% women; 12 months follow-up Conclusion: counselling patients in general practice on exercise is effective in increasing physical activity and improving quality of life over 12 months Raina Elley C, et al. BMJ 2003;326:793