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Mechanical properties and in vitro characterization of polyvinyl alcohol-nano-silver hydrogel wound dressings by R. N. Oliveira, R. Rouzé, B. Quilty, G.

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Presentation on theme: "Mechanical properties and in vitro characterization of polyvinyl alcohol-nano-silver hydrogel wound dressings by R. N. Oliveira, R. Rouzé, B. Quilty, G."— Presentation transcript:

1 Mechanical properties and in vitro characterization of polyvinyl alcohol-nano-silver hydrogel wound dressings by R. N. Oliveira, R. Rouzé, B. Quilty, G. G. Alves, G. D. A. Soares, R. M. S. M. Thiré, and G. B. McGuinness Interface Focus Volume 4(1):20130049 February 6, 2014 ©2014 by The Royal Society

2 Microstructural analysis: (a) XRD patterns and (b) FT-IR spectra of the hydrogel samples. R. N. Oliveira et al. Interface Focus 2014;4:20130049 ©2014 by The Royal Society

3 AFM line profiles based on the topographic images of (a) PVA and of (b) 0.25 and AFM phase images of (c) PVA and of (d) 0.25. R. N. Oliveira et al. Interface Focus 2014;4:20130049 ©2014 by The Royal Society

4 Inhibition pattern of all samples against S. aureus (6538), E. coli (25992) and C. albicans (10231). *p < 0.05, sig. = 1. R. N. Oliveira et al. Interface Focus 2014;4:20130049 ©2014 by The Royal Society

5 Cytotoxicity tests. R. N. Oliveira et al. Interface Focus 2014;4:20130049 ©2014 by The Royal Society

6 Swelling degree of the samples in (a) saline solution, (b) PBS pH 7.4 and (c) solution pH 4.0. R. N. Oliveira et al. Interface Focus 2014;4:20130049 ©2014 by The Royal Society

7 ESD of (a) the different samples immersed in each medium (saline solution, PBS pH 7.4 and solution pH 4.0) and of (b) sample composition (PVA, 0.25 and 0.50) in the different media. *p < 0.05, sig. = 1. R. N. Oliveira et al. Interface Focus 2014;4:20130049 ©2014 by The Royal Society

8 Weight loss (WL) of (a) the different samples in same medium and of (b) the samples of the same composition in the different media. *p < 0.05, sig. = 1. R. N. Oliveira et al. Interface Focus 2014;4:20130049 ©2014 by The Royal Society

9 UV–visible spectra of one curve of 0.25 samples and of one curve of 0.50 samples in each media. R. N. Oliveira et al. Interface Focus 2014;4:20130049 ©2014 by The Royal Society

10 Silver nanoparticle delivery (approx. 450 nm): (a) various sample compositions in the same media and (b) the same sample composition in the different media. *p < 0.05, sig. = 1. R. N. Oliveira et al. Interface Focus 2014;4:20130049 ©2014 by The Royal Society

11 Average tensile curves for the various sample compositions in (a) saline, (b) PBS pH 7.4 and (c) solution pH 4.0 after 1 day of immersion (n = 10) and (d) gels' equilibrium swelling degree (ESD) values. R. N. Oliveira et al. Interface Focus 2014;4:20130049 ©2014 by The Royal Society

12 Mechanical properties of the gels: (a) secant modulus E at 50% strain, (b) strain at failure e, (c) strength at failure σF for each sample composition in different media and (d) strength at failure in each medium for the various sample compositions. R. N. Oliveira et al. Interface Focus 2014;4:20130049 ©2014 by The Royal Society


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