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Mathematical models of immune-induced cancer dormancy and the emergence of immune evasion by Kathleen P. Wilkie, and Philip Hahnfeldt Interface Focus Volume.

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Presentation on theme: "Mathematical models of immune-induced cancer dormancy and the emergence of immune evasion by Kathleen P. Wilkie, and Philip Hahnfeldt Interface Focus Volume."— Presentation transcript:

1 Mathematical models of immune-induced cancer dormancy and the emergence of immune evasion by Kathleen P. Wilkie, and Philip Hahnfeldt Interface Focus Volume 3(4): August 6, 2013 ©2013 by The Royal Society

2 Immune cytotoxicity assay data and model fits for predation decay after 0, 35, 60, 90, 120 or 365 days in dormancy. Kathleen P. Wilkie, and Philip Hahnfeldt Interface Focus 2013;3: ©2013 by The Royal Society

3 Bifurcation diagrams and bifurcation phase portrait for the cancer–immune dormant state. Kathleen P. Wilkie, and Philip Hahnfeldt Interface Focus 2013;3: ©2013 by The Royal Society

4 Simulations of immune-mediated tumour dormancy assuming the three fits to predation decay. Kathleen P. Wilkie, and Philip Hahnfeldt Interface Focus 2013;3: ©2013 by The Royal Society

5 Population growth curves assuming the three fits in predation decay and that the immune response is limited. Kathleen P. Wilkie, and Philip Hahnfeldt Interface Focus 2013;3: ©2013 by The Royal Society

6 Simulations of immune-mediated tumour dormancy assuming the three fits for decay are applied to the recruitment potential while the predation strength is constant. Kathleen P. Wilkie, and Philip Hahnfeldt Interface Focus 2013;3: ©2013 by The Royal Society

7 Simulations of immune-mediated tumour dormancy assuming the three fits for decay are applied to both the predation strength and the recruitment potential. Kathleen P. Wilkie, and Philip Hahnfeldt Interface Focus 2013;3: ©2013 by The Royal Society

8 The transition of a heterogeneous cancer population to a mostly homogeneous but resistant population can explain the observed decline in predation efficacy. Kathleen P. Wilkie, and Philip Hahnfeldt Interface Focus 2013;3: ©2013 by The Royal Society


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