24. Plants and humans have evolved together over hundreds of thousands of years & plant molecules are familiar to human system. Herbal medicines relatively well tolerated with fewer adverse reactions than pharmaceutical drugs although natural doesn’t equal safe!

25. Herbal medicines effective tools to restore disrupted physiology as in many chronic functional disorders e.g. IBS, migraine, insomnia, fibromyalgia, nonspecific joint pain, irritable bladder, insomnia and tiredness, low mood and anxiety.

26. Because of emphasis to restore normal physiological balance rather than treating particular diseases, herbal medicines often described in terms of their actions — carminative, laxative, demulcent, antitussive, expectorant, sedative, antiseptic, or astringent.

27. Many plants synthesize substances that are useful to the maintenance of health in humans. These include aromatic substances, most of which are phenols or their derivatives such as tannins. Many are secondary metabolites, of which at least 12,000 have been isolated —estimated to be less than 10% of the total. In many cases, these substances (e.g. alkaloids and tannins) serve as plant defence mechanisms against predation by microorganisms, insects, and herbivores.

28. “The long tradition of the medicinal product makes it possible to reduce the need for clinical trials, in so far as the efficacy of the medicinal product is plausible on the basis of longstanding use and experience. “Pre‐clinical tests do not seem necessary, where the medicinal product on the basis of the information on its traditional use proves not to be harmful in specified conditions of use.

29. “However, even a long tradition does not exclude the possibility that there may be concerns with regard to the product's safety, and therefore the competent authorities should be entitled to ask for all data necessary for assessing the safety. The quality aspect of the medicinal product is independent of its traditional use so that no derogation should be made with regard to the necessary physicochemical, biological and microbiological tests.”