1. TEMPLATE DESIGN © 2008 www.PosterPresentations.com Uterine sarcomas in RIPAS Hospital, Brunei; a 10 year retrospective study. Dr Alice Kurien, Dr Saw Ohnmar, Dr Hjh Roselina Yaakub. Department of Obstetrics & Gynaecology, RIPAS Hospital, Brunei Darussalam Objectives To evaluate :  Demographic profile  Risk factors  Diagnostic issues  Clinical outcome Methods Results Total cases of uterine corpus cancer -156 Uterine Sarcoma - 37(23.7% ). Conclusions References Higher proportion of uterine sarcoma among women with corpus cancer in Brunei. Mean Age was 47.8 years One or more risk factors in 78 % patients. Multiple risk factors noted in 30% 63% are disease free after 5 years follow up. 70% are alive & well. Disease stage was the most important prognostic factor. Further research is required to identify the cause of higher incidence in the study population. LOGO OPTIONAL HERE Yearly distribution Year 2001020304050607080910 No.3202155757 Parity distribution ParityNumber% 0718.92 2-42362.16 5& >718.92 Menopausal statusNumber% Pre menopausal2978.38 Post menopausal821.62 Pre op DiagnosisIntra op DiagnosisPost op diagnosis 5230 13.51%5.41%81.08 % HistologyNumber% Leiomyosarcoma (LMS)- Low grade Carcinosarcoma(MMMT) 1818 35.14 21.62 LMS -High grade Endometrial stromal sarcoma 7474 18.92 10.81 Endometrial Sarcoma (High grade) Adenosarcoma 4141 10.81 2.70 All patients with uterine sarcoma registered in the department of Obstetrics and Gynaecology in RIPAS hospital from 2001 to 2010 were studied. Cases were identified through the gynaecology oncology registry of the department. This was a retrospective case file analysis. The data was recorded in a pre- designed proforma and a detailed analysis was done. Prior approval from Brunei Darussalam Medical & Health Research Ethics Committee was obtained. SymptomNumber% Abnormal uterine bleeding (AUB),Mass Abdomen 1129.73 Mass abdomen1027.03 AUB924.32 AUB +Mass +pressure symptoms25.41 AUB+ pain25.41 AUB+ Mass +pain12.7 Pain + Mass,+pressure symptoms12.7 Vaginal discharge + mass p/v12.7 StageNumberAliveDied I26 Nil II22Nil III422 (50%) IV514 (75%) Age distribution FIGO stage 1. Vanessa N Harry et al. Review uterine sarcomas: The Obstetrician & Gynaecologist.2007; 9: 88-94. 2 Jonathan S Berek, Neville F Hacker: Practical Gynecologic Oncology 4 th edition.2005; 430-435. 3. Michael Quinn et al: Malignant disease of the uterus. Shaw’s text book of gynecology th edition 644-8. 4.McCluggage WG Uterine carcinosarcomas (malignant mixed mullerian tumors) are metaplastic carcinomas. I nt J Gynecol Cancer.2002 Nov-Dec;12(6):687-90 5.Kernochan LE,Garcia RL. Carcinosarcomas (malignant mixed mullerian tumor) of the uterus: advances in elucidation of biologic and clinical characteristics. 6. Zelmanowicz et al.Evidence for a common etiology for endometrial carcinoma and MMMT. Gynaecol Oncol 1998;69:253-257 7. Norris HJ, Taylor HB. Post irradiation sarcomas of the uterus. Obstet Gynaecol1965; 26:689-693. 8 Philip J. DiSaia, William T.Creasman. Clinical Gynecologic oncology.169-74. Survival status RISK FACTORS