1. Biology 342

2.  Welcome to the world of infectious diseases  Biology 342 The New Plagues  Stan Wright  530-878-0420  LIH 205  TTH – 5:30PM – 6:50PM

3.  History of Infectious Diseases  Natural history of infectious diseases  Agents causing emerging/remerging infectious diseases= “EID’s”  Reasons for emergence of infectious diseases  Solutions

4. D2L class site http://d2L.losrios.edu  class notes, Powerpoints/ppts, study guides  Download ppts before class, bring to class  Bio 342 The New Plagues Reader, parts1(and2): available free online at class website.  Emerging Infectious Diseases  Stuart Hill optional

5.  Biology: Science for Life with physiology. C. Belk and V. Maier Custom edition for SCC - NOT THE WHOLE BOOK (loose- leaf).Optional. Valuable for students with little/no biology background  Optional: Schaechter’s Mechanisms of Microbial Disease (3rd or 4th editions). Valuable for students who are very interested in infectious diseases.

6.  Attendance and participation  Reading assignments  Exams/Quizzes/Final  Presentation

7.  Exams: mixed format; multiple choice, fill-in, short answer, short essay  Study guides provided online in New Plagues Reader  Quizzes, exams are CLOSED BOOK, no notes unless otherwise stated

8.  No makeup quizzes, exams, or class presentations  If only 1 lecture exam missed, final exam percentage score is used for replacement score

9. If all quizzes taken, lowest 2 quiz scores are dropped no make-up quizzes Final exam: percentage score will be doubled to replace lowest lecture exam score

10.  Comprehensive - general questions covering course with a focus on last part of course.  Sign up for presentation date

11.  Choose an infectious disease, preferably an EID (list available; sign-up date later)  Poster /oral presentation towards end of semester -- Sign up for presentation dates.

12.  Evolution and Natural Selection  Need to understand as influences the spread of antibiotic resistance/drug resistance

13.  “disease”=dis-ease  An abnormal bodily condition that impairs functioning and can usually be recognized by signs and symptoms

14.  Infectious disease: disease caused by colonization of host organism by pathogenic microbe  patho=Greek: suffering, disease  pathogen: agent causing disease/harm; a parasite  pathogenic: causes disease

15.  “Overlap” between host, pathogen and environmental factors leads to infectious disease  Understanding the interplay of these factors can help prevent/control outbreaks of infectious diseases

16.  To understand infectious disease, need to understand symbiosis  Symbiosis: two organisms/agents living together  3 types of symbiosis

17.  1. Mutualism = both partners benefit  2.Commensalism = one partner benefits, second partner neither harmed nor benefits  3. Parasitism = one partner benefits, second partner is harmed – Pathogens are parasites

18.  2 symbiotic partners in parasitism:  1. Host:  partner in which parasite/pathogen lives,  partner which is harmed ”loser”  2. Parasite/pathogen:  partner which harms its partner/ host, partner  which benefits -”winner”

19.  Many pathogens are “microbes”, organisms or agents too small to be seen with the naked eye such as viruses, bacteria, and protozoa.

20.  microbes which normally could not harm host yet under special circumstances (e.g. lowered host defenses), opportunistic microbes can cause serious disease

21.  Larger organisms that can harm their host and can be seen with the naked eye are often referred to as “parasites”  ticks, fleas, worms  Ectoparasites  live on outside surface of host  ticks, fleas (blood feeders)  may act as vectors  Endoparasites – live within host - worms

22. 1. What is symbiosis? 2. Describe and give an example of: Mutualism Commensalism & Parasitism 3. What is a host, pathogen and parasite? 4. What is an infectious disease? 5. What are 3 factors which contribute to infectious disease?